Multicenter Retrospective Analysis About the Clinical Characteristics of Korean Paroxysmal Nocturnal Hemoglobinuria (PNH) Patients

Overview

Paroxysmal nocturnal hemoglobinuria (PNH) is a hematopoietic stem cell disorder in which unregulated activation of the complement system leads to significant ischemic morbidities with shortened lifespan. Life-threatening thromboembolism (TE) is the most feared complication of PNH, accounting for up to 45% of patient deaths. It is estimated that 40% of PNH patients experience a clinically evident TE and 60% of patients without clinically diagnosed TE demonstrate TE by high-sensitivity MRI, indicating the ongoing thrombotic risk in most patients with PNH. Much of these data come from PNH patients from European descent. To understand the impact of TE in patients with PNH from non-European regions, we performed this study to evaluate the clinical characteristics of Korean patients with PNH.

Full Title of Study: “Multicenter Retrospective Analysis About the Clinical Characteristics of Korean Patients With PNH”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Retrospective
  • Study Primary Completion Date: November 2010

Detailed Description

To evaluate the clinical characteristics in Korean PNH patients

Participating in This Clinical Trial

Inclusion Criteria

  • Diagnosis confirmed by Ham's test or Flow cytometry Patients have any Flow cytometry data Exclusion Criteria:

  • Patients have no Flow cytometry data

Gender Eligibility: All

Minimum Age: 1 Year

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Samsung Medical Center
  • Provider of Information About this Clinical Study
    • Jun Ho Jang, Aplastic Working Party, The Korean Society of Hematology
  • Overall Official(s)
    • Jun Ho Jang, M.D., Principal Investigator, Samsung Medical Center

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