Acute Neurocardiogenic Injury After Subarachnoid Hemorrhage.

Overview

The aim of this study is to describe acute neurocardiogenic injury after subarachnoid hemorrhage assessed with cardiac 123I-MIBG scintigraphy and 18F-FDG PET/CT during the first week and the first six months after SAH. The study hypothesis is that the evolution of the cardiac disturbances follows the clinical evolution.

Full Title of Study: “Acute Neurocardiogenic Injury After Subarachnoid Hemorrhage Assessed With Cardiac 18F-FDG PET and 123I-MIBG Scintigraphy: a Prospective Observational Study.”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: February 2012

Detailed Description

The cardiac metabolic disturbance are assessed by a 18F-FDG PET/CT in the first week after SAH and monthly until normal result. The myocardial sympathetic innervation is assessed by a cardiac 123I-MIBG scintigraphy in the first week after SAH and six months later. Clinical outcome is assessed by Glasgow Outcome Scale, modified Rankin Scale and MOS-SF36 at 1, 3 and 6 months after SAH.

Arms, Groups and Cohorts

  • Subarachnoid hemorrhage
    • Patients presenting a SAH

Clinical Trial Outcome Measures

Primary Measures

  • cardiac 18F-FDG PET
    • Time Frame: first week after SAH

Secondary Measures

  • cardiac 123I-MIBG scintigraphy
    • Time Frame: first week after SAH
  • cardiac 18F-FDG PET
    • Time Frame: one month after first cardiac 18F-FDG PET
  • cardiac 123I-MIBG scintigraphy
    • Time Frame: Six months after SAH

Participating in This Clinical Trial

Inclusion Criteria

  • age – SAH – Hospitalization in the Military Teaching Hospital Sainte Anne Exclusion Criteria:

  • Refusal of consent

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Direction Centrale du Service de Santé des Armées
  • Provider of Information About this Clinical Study
    • Principal Investigator: PRUNET Bertrand, MD,MSc – Direction Centrale du Service de Santé des Armées
  • Overall Official(s)
    • Eric MEAUDRE, Professor, Study Director, Military Teaching Hospital Sainte Anne

References

Banki NM, Kopelnik A, Dae MW, Miss J, Tung P, Lawton MT, Drew BJ, Foster E, Smith W, Parmley WW, Zaroff JG. Acute neurocardiogenic injury after subarachnoid hemorrhage. Circulation. 2005 Nov 22;112(21):3314-9. doi: 10.1161/CIRCULATIONAHA.105.558239. Epub 2005 Nov 14.

Citations Reporting on Results

Meaudre E, Jego C, Kenane N, Montcriol A, Boret H, Goutorbe P, Habib G, Palmier B. B-type natriuretic peptide release and left ventricular filling pressure assessed by echocardiographic study after subarachnoid hemorrhage: a prospective study in non-cardiac patients. Crit Care. 2009;13(3):R76. doi: 10.1186/cc7891. Epub 2009 May 20.

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