Make up for the Epinephrine Autoinjector

Overview

Part of the problems related with proper use of epinephrine autoinjector may be related with the design of the autoinjector itself.The aim of the study is to investigate whether minor modifications in the design of currently available epinephrine autoinjector ease its use and abrogate common use errors.

Full Title of Study: “Make up for the Epinephrine Autoinjector: Effect on Its Use by Untrained Users”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Masking: None (Open Label)
  • Study Primary Completion Date: April 2010

Detailed Description

All interns except the ones who previously worked in allergy department in a medical school were invited to the study. Two identical epinephrine autoinjector trainers (Epipen trainer®) were used, one of which was modified by changing gray safety cap to red and placing a yellow arrow pointing to the black injection tip. Written and visual instruction sheet for each trainer was provided. Participants were asked to demonstrate the use of Epipen trainer either with the original or the modified one. They were scored and timed for demonstration. Primary study parameter was the rate of participants correctly demonstrating the use of epinephrine autoinjector. Secondary study parameters were the mean total score, mean time required to administer autoinjector and unintentional self injection of autoinjector into thumb.

Interventions

  • Device: Epinephrine autoinjector
    • We used 2 epinephrine autoinjector trainers and wrapped them by a gray sticky paper. Then,modified one of the trainers by changing gray safety cap to red with an atomizer paint and placing a yellow arrow pointing to the black injection tip.We provided three-step written and visual instruction sheet to use epinephrine autoinjector in Turkish same as given on the original trainer and changed that of the second trainer according to the modifications we made. Scoring system originally devised by Sicherer et al was used. Participants successively doing all steps were accepted to demonstrate autoinjector use correctly. Participants who tackled with black tip of autoinjector in order to eject needle after removing safety cap was regarded as unsuccessful since this may cause unintentional injection of epinephrine. All participants were scored and timed separately.

Arms, Groups and Cohorts

  • Other: Original epinephrine autoinjector group
    • Participants were given original epinephrine autoinjector trainer wrapped by a gray sticky paper.
  • Active Comparator: Modified epinephrine autoinjector group
    • Participants were given the same epinephrine autoinjector trainer wrapped by a gray sticky paper which was modified by changing gray safety cap to red with an atomizer paint and placing a yellow arrow pointing to the black injection tip.

Clinical Trial Outcome Measures

Primary Measures

  • Rate of participants correctly demonstrating the use of epinephrine autoinjector.

Secondary Measures

  • Mean total score participants get during demonstration of epinephrine autoinjector use
  • Mean time required to administer epinephrine autoinjector
  • Unintentional self injection of autoinjector into thumb

Participating in This Clinical Trial

Inclusion Criteria

We invited all interns in our faculty to inform about the study and included the ones who gave informed consent - Exclusion Criteria:

Interns who previously worked in allergy department were excluded. -

Gender Eligibility: All

Minimum Age: 21 Years

Maximum Age: 26 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Gazi University
  • Provider of Information About this Clinical Study
  • Overall Official(s)
    • Arzu Bakirtas, Principal Investigator, Gazi Universitry Faculty of Medicine, Department of Pediatric Allergy and Asthma
    • Mustafa Arga, Principal Investigator, Gazi Universitry Faculty of Medicine, Department of Pediatric Allergy and Asthma
    • Ferhat Catal, Principal Investigator, Gazi Universitry Faculty of Medicine, Department of Pediatric Allergy and Asthma
    • Oksan Derinoz, Principal Investigator, Gazi Universitry Faculty of Medicine, Department of Pediatric Emergency
    • Sadik M Demirsoy, Study Director, Gazi Universitry Faculty of Medicine, Department of Pediatric Allergy and Asthma
    • Ipek Turktas, Study Director, Gazi Universitry Faculty of Medicine, Department of Pediatric Allergy and Asthma

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