Metformin for Treatment Antipsychotic Induced Amenorrhea in Female Schizophrenic Patients


Antipsychotics such as risperidone could induce amenorrhea in schizophrenic patients. The investigators conducted a randomized, placebo-controlled study to test the efficacy of metformin for antipsychotic induced amenorrhea in schizophrenia patients.

Full Title of Study: “Metformin for Treatment Antipsychotic Induced Amenorrhea in Female Schizophrenic Patients: a Double Blind, Placebo-controlled Study”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
  • Study Primary Completion Date: January 2010


  • Drug: metformin

Arms, Groups and Cohorts

  • Experimental: metformin

Clinical Trial Outcome Measures

Primary Measures

  • prolactin level

Secondary Measures

  • fasting glucose

Participating in This Clinical Trial

Inclusion Criteria

  • schizophrenia patient
  • amenorrhea for more than three months after antipsychotic treatment

Exclusion Criteria

  • liver or renal diseases
  • pregnant or lactating women
  • cardiovascular diseases
  • hypertension or diabetes mellitus

Gender Eligibility: Female

Minimum Age: 18 Years

Maximum Age: 40 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Central South University
  • Provider of Information About this Clinical Study
    • Jingping Zhao, the Second Xiangya Hospital of Central South University
  • Overall Official(s)
    • Jingping Zhao, MD, Principal Investigator, Institute of Mental Health of The Second Xiangya Hospital, Central South University, 139# Renmin Middle Road´╝îChangsha 410011, Hunan, P.R. China

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