Metformin for Treatment Antipsychotic Induced Amenorrhea in Female Schizophrenic Patients

Overview

Antipsychotics such as risperidone could induce amenorrhea in schizophrenic patients. The investigators conducted a randomized, placebo-controlled study to test the efficacy of metformin for antipsychotic induced amenorrhea in schizophrenia patients.

Full Title of Study: “Metformin for Treatment Antipsychotic Induced Amenorrhea in Female Schizophrenic Patients: a Double Blind, Placebo-controlled Study”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
  • Study Primary Completion Date: January 2010

Interventions

  • Drug: metformin

Arms, Groups and Cohorts

  • Experimental: metformin

Clinical Trial Outcome Measures

Primary Measures

  • prolactin level

Secondary Measures

  • fasting glucose

Participating in This Clinical Trial

Inclusion Criteria

  • schizophrenia patient
  • amenorrhea for more than three months after antipsychotic treatment

Exclusion Criteria

  • liver or renal diseases
  • pregnant or lactating women
  • cardiovascular diseases
  • hypertension or diabetes mellitus

Gender Eligibility: Female

Minimum Age: 18 Years

Maximum Age: 40 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Central South University
  • Provider of Information About this Clinical Study
    • Jingping Zhao, the Second Xiangya Hospital of Central South University
  • Overall Official(s)
    • Jingping Zhao, MD, Principal Investigator, Institute of Mental Health of The Second Xiangya Hospital, Central South University, 139# Renmin Middle Road´╝îChangsha 410011, Hunan, P.R. China

Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.

At TrialBulletin.com, we keep tabs on over 200,000 clinical trials in the US and abroad, using medical data supplied directly by the US National Institutes of Health. Please see the About and Contact page for details.