GDF 15 in Sickle Cell Disease and Hereditary Spherocytosis
Overview
Patients with thalassemia intermedia, congenital dyserythropoietic anemia type I , and sideroblastic anemia were found to express very high levels of serum GDF15, and this contributed to the inappropriate suppression of hepcidin with subsequent secondary iron overload.The aim of our present study is to asses the levels of GDF15 and hepcidin in patients with Sickle cell disease and hereditary spherocytosis
Full Title of Study: “The Impact of Growth Differentiating Factor (GDF) 15 in Sickle Cell Disease and Hereditary Spherocytosis”
Study Type
- Study Type: Observational
- Study Design
- Time Perspective: Prospective
- Study Primary Completion Date: September 2011
Detailed Description
The identification of the ferroportin/hepcidin axis has allowed the effect of erythroid activity on iron balance to be studied and has created the basis for better defining the erythroid regulators. In iron-loading anemias, ineffective erythropoiesis suppresses hepcidin production, which result in dysregulating iron homeostasis. Miller and co-workers showed that release of cytokines like growth differentiation factor 15 (GDF15) during the process of ineffective erythropoiesis inhibits hepcidin production, thus defining a molecular link between ineffective erythropoiesis, suppression of hepcidin production and parenchymal iron loading.
Arms, Groups and Cohorts
- Sickle cell disease
- hereditary spherocytosis.
Clinical Trial Outcome Measures
Primary Measures
- GDF 15
- Time Frame: year
Secondary Measures
- Hepcidine
- Time Frame: year
Participating in This Clinical Trial
Inclusion Criteria
- non Exclusion Criteria:
- non
Gender Eligibility: All
Minimum Age: 5 Years
Maximum Age: N/A
Are Healthy Volunteers Accepted: No
Investigator Details
- Lead Sponsor
- Wolfson Medical Center
- Provider of Information About this Clinical Study
- Dr’ Ghoti Hossam, hematology department on Wolfsson Medical Center
- Overall Official(s)
- GHOTI HOSSAM, doctor, Principal Investigator, HEMATOLOGY DEPARTMENT ON WOLFSSON MEDICAL CENTER
- Overall Contact(s)
- Ghoti Hossam, doctor, 035028110, drghoti123@yahoo.com
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