Effect of Aqueous Extract of Garlic and Nystatin Mouthwash in Denture Stomatitis

Overview

The aim of the present study was to compare the effect of aqueous extract of garlic with nystatin mouthwash in denture stomatitis.

Full Title of Study: “Comparison of Therapeutic Effect of Aqueous Extract of Garlic and Nystatin Mouthwash in Denture Stomatitis”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Treatment
    • Masking: Double (Participant, Investigator)
  • Study Primary Completion Date: September 2010

Detailed Description

Denture stomatitis is the most common form of chronic oral candidiasis manifested as chronic inflammation of the mucous membrane t supporting the movable prosthesis that may have a local or systemic nature. This inflammation is presented as mucous erythema and occasionally with pain and burning. The standard treatment for denture stomatitis is administration of nystatin which is accompanied with complications such as bitter taste as well as the high number of drug application that result in reduced tendency of patients in using this medication hence, efforts are continuously being made to substitute other types of therapies for this condition.

Interventions

  • Drug: garlic , nystatin
    • mouthwash

Arms, Groups and Cohorts

  • Other: drug: garlic extract, nystatin
    • Drug: garlic extract 40mg/dl or nystatin suspension 100000 iu/ml tid for one month Patients had been clinically with denture stomatitis and confirmed by oral medicine specialist were selected for the study. Gender, age, medical history, erythema types, size, and other treatment used for this disease were recorded. Local ethical committee approval was obtained before the trial started and all patients gave written informed consent. Patients were randomly divided into two groups .First group received garlic extract and second group used nystatin suspension for 1 month. Each patients was examined at the beginning of the therapy ,and then every 1 weeks up to 1 months .

Clinical Trial Outcome Measures

Primary Measures

  • reduction of diameter of erythematous lesion under denture
    • Time Frame: first week
    • measuring erythematous lesion by visual and then photography and a colis

Secondary Measures

  • complete relief of erythematous lesions
    • Time Frame: fourth week

Participating in This Clinical Trial

Inclusion Criteria

  • 40 years of age and older – confirm of denture stomatitis by the oral medicine specialists Exclusion Criteria:

  • Patients with a history of using anti-fungal drugs, antibiotics, and corticosteroid within the previous month – allergy to garlic and nystatin mouthwash – immunodeficiency – uncontrolled diabetes – those with garlic rich diet – inability in using mouthwash – loose and discolored dentures – psychologic disorder and alzheimer

Gender Eligibility: All

Minimum Age: 40 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Qazvin University Of Medical Sciences
  • Provider of Information About this Clinical Study
    • Comparison of therapeutic effect of aqueous extract of garlic and nystatin mouthwash in denture stomatitis, Qazvin University of Medical Science
  • Overall Official(s)
    • mahin bakhshi, DDS,MS, Study Chair, Qazvin University of Medical Science
    • Jamileh bigom Taheri, DDS/MS, Study Director, Shahid Beheshti University of Medical Science
    • Samira Basir Shabestari, DDS/MS, Principal Investigator, QUMS
    • Rozbeh Pahlevan, DDS, Principal Investigator, QUMS
    • Anet Tanic, DDS, Principal Investigator, QUMS

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