Immune Dysregulation in Hepatitis C Patients With or Without Arthritis

Overview

The purpose of this study is to study the role of the Immune System in causing arthritis in patients with Hepatitis C.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: August 2011

Detailed Description

Patients will provide one blood sample after qualifying for the study, and signing consent. The patients will have a skin test TB, Candida, and Trichophyton placed and will read the results themselves and mail back the card with the measurements to be recorded. Labs will test for ESR, CBC, CRP, antiCCP, Cryoglobulins, RF, CH50, C3, C4, Flow cytometry, and would have already been tested for HIV and Hepatitis C.

Arms, Groups and Cohorts

  • Hepatitis C with Arthritis
  • Hepatitis C without Arthritis

Participating in This Clinical Trial

Inclusion Criteria

  • All adults 18 or older, 20 will have hep C positive with a viral load withen 6 mo. of enrollment. – Either interferon or antiviral naive or those who failed interferon or antiviral therapy more than 6 mo. prior to enrollment. – 10 normal healthy controls- Hep C neg and without osteoarthritis (OA). Exclusion Criteria:

  • HIV patients – Those with concomitant alcoholic liver disease – Patients with Rheumatoid Arthritis (RA) or other autoimmune disorders.

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • The Center for Rheumatic Disease, Allergy, & Immunology
  • Collaborator
    • St. Luke’s Hospital
  • Provider of Information About this Clinical Study
    • Dr. Nabih I Abdou, PhD, Center for Rheumatic Disease, Allergy, & Immunology
  • Overall Official(s)
    • Nabih I Abdou, MD, PhD, Principal Investigator, Center for Rheumatic Disease, Allergy & Immunology
  • Overall Contact(s)
    • Nabih I Abdou, MD, PhD, 816-531-0930

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