Reference Values of Cerebrospinal Fluid Outflow Resistance and Intracranial Pressure in Healthy Elderly


Objective. The intracranial pressure and cerebrospinal outflow resistance are essential parameters to describe the cerebrospinal fluid dynamic system. Outflow resistance effects intracranial pressure, pulse amplitudes, cerebrospinal fluid absorption as well as the compliance of the system. The objective of this study was to determine the reference values in the elderly. Methods. Elderly people (60-82 years), considering themselves healthy, were recruited through an ad in the local paper. All were evaluated with a 3 Tesla magnetic resonance imaging apparatus. Subjects were eligible if they did not have any psychiatric or neurological disorder or signs of advanced atherosclerotic disease. Intracranial pressure and outflow resistance were determined by a constant pressure infusion method with the patient in the supine position. The study population consisted of 40 subjects (mean age 70 years; 23 women).

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: December 2008


  • Procedure: CSF dynamic investigation

Arms, Groups and Cohorts

  • Healthy elderly
    • Healthy elderly 60-82 years; Normal MRI; No psychiatric or neurological disorder and without signs of advanced atherosclerotic disease

Clinical Trial Outcome Measures

Primary Measures

  • CSF outflow resistance

Secondary Measures

  • Intracranial pressure

Participating in This Clinical Trial

Inclusion Criteria

  • Healthy – 60-82 years Exclusion Criteria:

  • Psychiatric or neurological disorder or advanced atherosclerotic disease

Gender Eligibility: All

Minimum Age: 60 Years

Maximum Age: 82 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Umeå University
  • Provider of Information About this Clinical Study
    • Jan Malm, Dep Clinical Neuroscience
  • Overall Official(s)
    • Jan I Malm, PhD, MD, Principal Investigator, Umeå University

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