Study of Tocotrienol Absorption and Distribution Under Different Fat Status

Overview

Despite the emerging interest in tocotrienols, the absorption of tocotrienols in humans remains unclear especially with different fat diets.This study aimed at evaluating the absorption and distribution of tocotrienols in plasma and lipoproteins in associations with high and low fat diets. Different fat level will affect the absorption and distribution of tocotrienols

Full Title of Study: “Mechanism of Absorption and Distribution of Tocotrienols Under Different Food Status”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Crossover Assignment
    • Primary Purpose: Basic Science
    • Masking: Single (Participant)
  • Study Primary Completion Date: September 2009

Detailed Description

There is a possibility that the absorption and distribution of tocotrienols may occur differently compared with tocopherols, especially under different fat status

Interventions

  • Dietary Supplement: Tocotrienol
    • 500 mg of tocotrienol will be administered after consumption of high fat diet
  • Dietary Supplement: Tocotrienol
    • 500 mg of tocotrienol will be administered after consumption of low fat diet

Arms, Groups and Cohorts

  • Experimental: High fat
    • 500 mg of tocotrienol will be administered at single dose after consumption of high fat diet
  • Experimental: Low fat
    • 500 mg of tocotrienol will be administered at single dose after consumption of low fat diet

Clinical Trial Outcome Measures

Primary Measures

  • Difference in absorption and distribution of Tocoterienols during high fat and low fat meal by measuring the plasma, chylomicron, and HDL level of tocotrienol
    • Time Frame: 0, 0.5, 1, 1.5, 2, 3, 4, 5, 6, 24 hours after tocotrienol administration and in take of designated meal

Participating in This Clinical Trial

Inclusion Criteria

  • male aged 22-25 – body mass index 18.5 < X < 30 kg/m2 – plasma cholesterol < 5.2 mmol/L, – TAG < 1.7 mmol/L Exclusion Criteria:

  • history of cardiovascular disease – diabetic – body mass index < 18.5 or > 30 kg/m2 – plasma cholesterol > 5.2 mmol/L, – TAG > 1.7 mmol/L – hypertension – currently taking Vitamin E supplement – current use of medication – smoking.

Gender Eligibility: Male

Minimum Age: 22 Years

Maximum Age: 25 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Malaysia Palm Oil Board
  • Collaborator
    • University of Malaya
  • Provider of Information About this Clinical Study
    • Wong Weng-Yew / Research Officer, Malaysian Palm Oil Board
  • Overall Official(s)
    • Weng-Yew Wong, Bsc, Principal Investigator, Malaysia Palm Oil Board

Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.

At TrialBulletin.com, we keep tabs on over 200,000 clinical trials in the US and abroad, using medical data supplied directly by the US National Institutes of Health. Please see the About and Contact page for details.