Study of Tocotrienol Absorption and Distribution Under Different Fat Status
Overview
Despite the emerging interest in tocotrienols, the absorption of tocotrienols in humans remains unclear especially with different fat diets.This study aimed at evaluating the absorption and distribution of tocotrienols in plasma and lipoproteins in associations with high and low fat diets. Different fat level will affect the absorption and distribution of tocotrienols
Full Title of Study: “Mechanism of Absorption and Distribution of Tocotrienols Under Different Food Status”
Study Type
- Study Type: Interventional
- Study Design
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Primary Purpose: Basic Science
- Masking: Single (Participant)
- Study Primary Completion Date: September 2009
Detailed Description
There is a possibility that the absorption and distribution of tocotrienols may occur differently compared with tocopherols, especially under different fat status
Interventions
- Dietary Supplement: Tocotrienol
- 500 mg of tocotrienol will be administered after consumption of high fat diet
- Dietary Supplement: Tocotrienol
- 500 mg of tocotrienol will be administered after consumption of low fat diet
Arms, Groups and Cohorts
- Experimental: High fat
- 500 mg of tocotrienol will be administered at single dose after consumption of high fat diet
- Experimental: Low fat
- 500 mg of tocotrienol will be administered at single dose after consumption of low fat diet
Clinical Trial Outcome Measures
Primary Measures
- Difference in absorption and distribution of Tocoterienols during high fat and low fat meal by measuring the plasma, chylomicron, and HDL level of tocotrienol
- Time Frame: 0, 0.5, 1, 1.5, 2, 3, 4, 5, 6, 24 hours after tocotrienol administration and in take of designated meal
Participating in This Clinical Trial
Inclusion Criteria
- male aged 22-25 – body mass index 18.5 < X < 30 kg/m2 – plasma cholesterol < 5.2 mmol/L, – TAG < 1.7 mmol/L Exclusion Criteria:
- history of cardiovascular disease – diabetic – body mass index < 18.5 or > 30 kg/m2 – plasma cholesterol > 5.2 mmol/L, – TAG > 1.7 mmol/L – hypertension – currently taking Vitamin E supplement – current use of medication – smoking.
Gender Eligibility: Male
Minimum Age: 22 Years
Maximum Age: 25 Years
Are Healthy Volunteers Accepted: Accepts Healthy Volunteers
Investigator Details
- Lead Sponsor
- Malaysia Palm Oil Board
- Collaborator
- University of Malaya
- Provider of Information About this Clinical Study
- Wong Weng-Yew / Research Officer, Malaysian Palm Oil Board
- Overall Official(s)
- Weng-Yew Wong, Bsc, Principal Investigator, Malaysia Palm Oil Board
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