Radiologic Features of Invasive Pulmonary Aspergillosis

Overview

Invasive pulmonary aspergillosis (IPA) is an opportunistic infection that primarily affects recipients of solid organ transplants (SOTs) and patients with chemotherapy- induced neutropenia.Although both of these populations are at high risk for IPA, they differ with regards to the specific defects in host defense mechanisms that increase their risk for IPA. Chemotherapy- induced neutropenia is the principal defect affecting patients with hematologic malignancies, whereas transplant recipients tend to have dysfunctional T cells and phagocytes, as a result of immunosuppressive drug therapy. Thus, the patterns of IPA-related infection and inflammation may differ according to the type of underlying immune defect. Although the clinical and radiological features of IPA in patients with neutropenia have been extensively studied, little is known about the characteristics of IPA in SOT recipients. The investigators therefore compared the IPA- related clinical and radiological findings in SOT recipients with those of neutropenic patients.

Full Title of Study: “Retrospective Analysis of Radiologic Features of Invasive Pulmonary Aspergillosis in Transplant Recipients and Neutropenic Patients.Transplant Recipients and Neutropenic Patients”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Retrospective
  • Study Primary Completion Date: February 2010

Arms, Groups and Cohorts

  • SOT recipients
    • solid organ transplant recipients with invasive pulmonary aspergillosis
  • Hematologic disease
    • Hematologic disease patients with invasive pulmonary aspergillosis

Participating in This Clinical Trial

Inclusion Criteria

  • IPA cases with solid organ transplant recipients and hematologic disease patients – proven and probable invasive pulmonary aspergillosis by modified EORTC/MSG criteria Exclusion Criteria:

  • under 16 years old – possible cases of invasive pulmonary aspergillosis

Gender Eligibility: All

Minimum Age: 16 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Asan Medical Center
  • Provider of Information About this Clinical Study
    • Principal Investigator: Sung-Han Kim, Assistantant Professor – Asan Medical Center
  • Overall Official(s)
    • Sung-Han Kim, MD, Study Chair, Department of Infectious Diseases, Asan Medical Center

Citations Reporting on Results

Park SY, Lim C, Lee SO, Choi SH, Kim YS, Woo JH, Song JW, Kim MY, Chae EJ, Do KH, Song KS, Seo JB, Kim SH. Computed tomography findings in invasive pulmonary aspergillosis in non-neutropenic transplant recipients and neutropenic patients, and their prognostic value. J Infect. 2011 Dec;63(6):447-56. doi: 10.1016/j.jinf.2011.08.007. Epub 2011 Aug 16.

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