Usefulness of Exhaled NO in the Differential Diagnosis Acute Eosinophilic Pneumonia and Bacterial Pneumonia

Overview

Acute eosinophilic pneumonia (AEP) is diagnosed by cell count analysis of bronchoalveolar lavage fluid. However, the performance of bronchoscopy is not easy for patients with AEP, because they usually have hypoxia. Exhaled nitric oxide (FeNO) is usually elevated in the patients with eosinophilic inflammation such as asthma, but there is no previous studies FeNO in the patients with AEP. Investigators hypothesized that FeNO elevated significantly in patients with AEP, and FeNO can be used as non-invasive diagnostic method in patients who are clinically suspected with AEP, especially when the performance of bronchoscopy is difficult.

Full Title of Study: “Usefulness of Exhaled NO in the Differential Diagnosis Acute Eosinophilic Pneumonia and Community Acquired Pneumonia”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: April 2011

Arms, Groups and Cohorts

  • Acute eosinophilic pneumonia
  • Community acquired pneumonia

Clinical Trial Outcome Measures

Primary Measures

  • The difference of FeNO in AEP and Community Acquired Pneumonia
    • Time Frame: Six months

Participating in This Clinical Trial

Inclusion Criteria

  • All patients who visited the study hospital with bilateral pneumonic infiltration. Exclusion Criteria:

  • Patients who do not agree with our study protocol

Gender Eligibility: All

Minimum Age: N/A

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Seoul National University Bundang Hospital
  • Provider of Information About this Clinical Study
    • Sei Won Lee/ Assistant Professor, Seoul National University Bundang Hospital

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