The Effect of Oxytocin on Gastric Emptying


The investigators have seen that oxytocin lowers satiety in healthy subjects. Patients with dyspepsia suffers from decreased accommodation and increased satiety postprandially. The investigators now want to examine whether oxytocin may diminish symptoms in these patients.

Full Title of Study: “The Effect of Oxytocin on Satiety in Patients With Dyspepsia”

Study Type

  • Study Type: Interventional
  • Study Design
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Treatment
    • Masking: Double (Participant, Care Provider)
  • Study Primary Completion Date: April 2015

Detailed Description

Patients will come twice for a slow satiety drinking test. Once they will get saline infusion and once oxytocin 40 mU/min. At the same time they register satiety on a VAS scale.


  • Drug: oxytocin
    • 40mU/min as infusion of oxytocin

Arms, Groups and Cohorts

  • Experimental: oxytocin, satiety
    • Oxytocin is given as infusion to examine if this decreases satiety compared to saline during a drinking test

Clinical Trial Outcome Measures

Primary Measures

  • Satiety
    • Time Frame: 2 h
    • The investigator want to examine whether oxytocin leads to lower satiety scores after intake of the same volume of nutrient

Participating in This Clinical Trial

Inclusion Criteria

  • Dyspepsia

Exclusion Criteria

  • Age > 65 years
  • Cardiac disease

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 65 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Skane University Hospital
  • Provider of Information About this Clinical Study
    • Principal Investigator: Bodil Ohlsson, Department of Clinical Sciences, Division of Internal Medicine – Skane University Hospital
  • Overall Official(s)
    • Bodil Ohlsson, professor, Principal Investigator, Divsion of Internal Medicine

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