Effects of Lycium Barbarum Supplements on the Progression of Senile Cataract in Hong Kong Chinese Population
Overview
With the rapid growing aging population, age-related eye diseases including cataract are becoming more prevalent. The demand for cataract surgery and post-surgical care posed enormous financial burdens to the government. Lycium barbarum contains lutein and zeaxanthin which can filter the phototoxic blue light and neutralize the reactive oxygen species, thus provide a protective effect against cataract formation. This study aims to determine the effects of Lycium barbarum Supplements on the progression of senile cataract in Hong Kong Chinese elderly.
Study Type
- Study Type: Interventional
- Study Design
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Primary Purpose: Prevention
- Masking: Double (Participant, Outcomes Assessor)
- Study Primary Completion Date: April 2012
Detailed Description
Please note that a manuscript for this study is being prepared. Detailed description will be provided after we come up with the final draft.
Interventions
- Dietary Supplement: Starch
- 1350mg/day
- Dietary Supplement: Lycium Barbarum
- 1350mg/day
Arms, Groups and Cohorts
- Active Comparator: Placebo
- Starch
- Experimental: Lycium Barbarum
- Lycium Barbarum supplement
Clinical Trial Outcome Measures
Primary Measures
- Lens Opacity Classification System III (LOCSIII)
- Time Frame: 3 years
Secondary Measures
- Visual Acuity
- Time Frame: 3 years
Participating in This Clinical Trial
Inclusion Criteria
- Unlikely to have cataract surgery within 3 years – Presence of mild to moderate cataract in one or both eyes, graded by Lens Opacities Classification System III (LOCSIII). – logMAR acuity equivalent to Snellen acuity of 20/63 or better – no previous history and clinical signs of glaucoma by determining intraocular pressure using applanation Tonometry (no more than 22mmHg) – no ocular anomalies: amblyopia, binocular anomalies, ocular trauma – no history of eye surgery, laser treatment, iritis, retinal crystalline deposits, macular degeneration, or optic nerve diseases – no extended use of systemic or ocular corticosteroid drugs – no concurrent participation of other systemic or ocular drug intervention study Exclusion Criteria:
- diabetes mellitus – renal failure – fat malabsorption syndrome – intestinal surgery history – chronic diarrhea – alcoholism – use of anticoagulants – regular use of nutritional supplements such as multi-vitamin, mineral and other antioxidant supplements (including Omega-3)
Gender Eligibility: All
Minimum Age: 60 Years
Maximum Age: 75 Years
Are Healthy Volunteers Accepted: Accepts Healthy Volunteers
Investigator Details
- Lead Sponsor
- The Hong Kong Polytechnic University
- Collaborator
- The Hong Kong Jockey Club Charities Trust
- Provider of Information About this Clinical Study
- Principal Investigator: Chea-su Kee, Associate Professor – The Hong Kong Polytechnic University
- Overall Official(s)
- Chi-wai Do, PhD, Principal Investigator, The Hong Kong Polytechnic University
- Chea-su Kee, PhD, Principal Investigator, The Hong Kong Polytechnic University
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