Tissue, Blood, and Body Fluid Sample Collection From Patients With Hematologic Cancer

Overview

RATIONALE: Collecting and storing samples of tissue, blood, and body fluid from patients with cancer to study in the laboratory may help the study of cancer in the future. PURPOSE: This research study is collecting and storing blood and tissue samples from patients being evaluated for hematologic cancer.

Full Title of Study: “Tissue Procurement For Hematolymphoid Conditions”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: July 2040

Detailed Description

OBJECTIVES: – Provide source of patient tissue, blood, and body fluid samples for ongoing diagnostic, prognostic, or immune-monitoring studies. – Support and enhance translational, clinical and basic research for Lineberger Comprehensive Cancer Center (LCCC) members (and non-members who have an LCCC member as sponsor and collaborator) with IRB-approved studies. – Maintain responsible and appropriate policies and procedures that ensure good patient care and responsible conduct of research. – Address medical and legal issues, and protect participant and patient privacy and confidentiality. – Provide a responsible and uniform mechanism for the integrated coordination of the hemato-pathologist and surgeon or hematology/oncology staff, researcher, and protocol office to obtain appropriate specimens for researchers. – Support young investigators to obtain pilot data for grant funding. OUTLINE: Patients undergo tissue, blood, and body fluid collection during diagnostic or routine procedures for future correlative studies. Tissue samples may include, but are not limited to, lymph node or non-nodal biopsies, bone marrow biopsy and/or aspirate, blood and serum, and buccal swabs for germline DNA analysis.

Interventions

  • Other: biologic sample preservation procedure
    • All samples collected during routine clinical care.
  • Other: cytology specimen collection procedure
    • All Samples collected during routine clinical care.

Clinical Trial Outcome Measures

Primary Measures

  • Tissue, blood, and body fluid samples collection for ongoing diagnostic, prognostic, or immune-monitoring studies
    • Time Frame: 30 years
  • Development of a centralized, quality-controlled, quality-assured facility for the procurement, processing, storage, and distribution of normal and malignant tissue specimens and corresponding blood specimens
    • Time Frame: 30 years

Participating in This Clinical Trial

DISEASE CHARACTERISTICS:

  • Diagnosis of abnormal hematopoietic/lymphoid cancer, including any of the following: – Acute myeloid leukemia – Acute lymphoblastic leukemia – Chronic myelogenous leukemia – Chronic lymphoid leukemia – Non-Hodgkin lymphoma – Hodgkin lymphoma – Myelodysplastic syndromes – Myeloproliferative disorders – Multiple myeloma – Waldenstrom macroglobulinemia – Aplastic anemia – Any other diseases that generate abnormalities in either number, function, or both of any cell type of hematolymphoid lineage – Patients who are being evaluated at the hematology/oncology clinics of the University of North Carolina Hospitals, at the stem cell transplant clinic, or in the hospital PATIENT CHARACTERISTICS: – Not specified PRIOR CONCURRENT THERAPY: – Not specified

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 120 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • UNC Lineberger Comprehensive Cancer Center
  • Collaborator
    • National Cancer Institute (NCI)
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Paul Armistead, MD, Principal Investigator, UNC Lineberger Comprehensive Cancer Center
  • Overall Contact(s)
    • Paul Armistead, MD, (919) 843-6847, paul_armistead@med.unc.edu

Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.

At TrialBulletin.com, we keep tabs on over 200,000 clinical trials in the US and abroad, using medical data supplied directly by the US National Institutes of Health. Please see the About and Contact page for details.