Evaluation of Oxidative Stress and Effect of Levothyroxine Treatment on Oxidative Stress in Hashimoto Disease

Overview

Oxidative stress leads to or accompanies with numerous disease. Oxidative balance in subclinical hypothyroid or euthyroid state in Hashimoto disease are not known. Effect of levothyroxine therapy on oxidative balance are also not known in hashimoto disease.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: April 2010

Detailed Description

oxidative stress markers will be measured initially(TAS,TOS,OSI,PARAOXONASE,ARYLESTERASA,PON1 PHENOTYPİNG,LİPİDPEROXİD).After 3 months therapy with levothyroxine measurements will be repeated except PON1 phenotyping.

Arms, Groups and Cohorts

  • healthy
  • euthyroid hashimoto
  • hypothyroid hashimoto

Clinical Trial Outcome Measures

Primary Measures

  • Poxidative stress markers
    • Time Frame: After levotren therapy

Participating in This Clinical Trial

Inclusion Criteria

  • age more than 18 years Exclusion Criteria:

  • inability to give a written consent – other conditions and drug usage affect oxidative stress

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 95 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Vakif Gureba Training and Research Hospital
  • Provider of Information About this Clinical Study
    • Principal Investigator: Mehmet Ali Cikrikcioglu, Vakif Gureba TRH – Vakif Gureba Training and Research Hospital
  • Overall Official(s)
    • Mehmet ali Cikrikcioglu, MD, Study Chair, vakif gureba TRH,fatih,istanbul,turkey.specialist in internal medicine

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