Corneal Endothelium Cell Loss After Cataract Extraction in Patients Taking Tamsulosin

Overview

The purpose of this study is to determine whether corneal endothelium cell loss during cataract surgery is higher in patients taking Tamsulosin.

Full Title of Study: “Corneal Endothelium Cell Loss After Cataract Extraction in Patients Taking Systemic Sympathetic Alfa-1-a-antagonist Medication (Tamsulosin)”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: September 2010

Detailed Description

Cataract surgery in patients taking Tamsulosin is regarded as more challenging for the surgeon because Intraoperative Floppy Iris Syndrome (IFIS) might occur. However, the question is whether this has any practical implication for the outcomes of surgery. In this study we investigate whether cornea is damage during surgery on Tamsulosin patient. In an observational study 30 cataract patients taking Tamsulosin is compared to 30 patients not taking Tamsulosin, but otherwise similar. Number of patients is based on power calculation. Cornea is examined by specular microscopy.

Arms, Groups and Cohorts

  • Tamsulosin
    • Patients taking tamsulosin
  • Non-tamsulosin
    • Patients not taking tamsulosin.

Clinical Trial Outcome Measures

Primary Measures

  • corneal endothelium cell loss
    • Time Frame: 3 months
    • Corneal endothelium cells was evaluated by specular microskopy before and 3 month post-operatively.

Participating in This Clinical Trial

Inclusion Criteria

  • cataract needing surgery Exclusion Criteria:

  • glaucoma – corneal scarring – diabetes – uveitis

Gender Eligibility: Male

Minimum Age: N/A

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Frederiksberg University Hospital
  • Provider of Information About this Clinical Study
    • Allan Storr-Paulsen, Frederiksberg University Hospital

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