Association of Polymorphisms in the Androgen Receptor Gene and Finasteride Response in Women With Androgenetic Alopecia

Overview

Previous studies of finasteride treatment in women with hair loss have failed to show positive results, yet, some women have responded anecdotally. Given that polymorphisms of the androgen receptor gene which confer androgen sensitivity impact male response to finasteride therapy, it was hypothesized that the same polymorphism in women may identify the group that will respond. This study is designed to test the impact of finasteride therapy on hair loss in postmenopausal women.

Full Title of Study: “Study Evaluating the Association of CAG Repeat Polymorphisms and Finasteride Response in Women With Androgenetic Alopecia”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Treatment
    • Masking: Single
  • Study Primary Completion Date: December 2009

Detailed Description

Androgen sensitivity in the cell is determined by the number of Cytosine-Adenine-Guanine repeats in the Androgen Receptor gene. Lower CAG repeats have been associated in previous studies with androgenic conditions such as acne, hirsutism and hair loss in men and women. Keeping this in mind, we tested women with hair loss in the frontal or vertex area, for their AR genotype. Patients were randomized to placebo or 1 mg finasteride therapy for 6 months. Global photographs and 2 tatooed areas of 1cm2 each were measured monthly to assess global appearance and hair counts for medication impact.

Interventions

  • Drug: Finasteride
    • Effect of 1 mg finasteride on women with androgenetic alopecia depending on their AR gene polymorphism (androgen sensitivity)

Arms, Groups and Cohorts

  • Other: androgen receptor gene polymorphism
    • Medication response will be assessed according to androgen receptor genotype
  • Active Comparator: finasteride
    • medication for treating androgenetic alopecia in women

Participating in This Clinical Trial

Inclusion Criteria

  • women with hair loss Exclusion Criteria:

  • pre menopausal, – metabolic or medication or non-androgenetic causes of hair loss, – diffuse hair loss

Gender Eligibility: Female

Minimum Age: N/A

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • HairDx, LLC
  • Provider of Information About this Clinical Study
    • Sharon Keene, M.D., HairDx
  • Overall Official(s)
    • Sharon A Keene, M.D., Principal Investigator, HairDx, LLC

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