Impact of Nebivolol on Central Aortic Pressure
Overview
A randomized, cross-over, single-blind study to compare the effects of nebivolol and metoprolol on central aortic pressure and peripheral brachial pressure in patients with stable cardiovascular disease.
Study Type
- Study Type: Interventional
- Study Design
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Primary Purpose: Treatment
- Masking: Single (Investigator)
- Study Primary Completion Date: May 2010
Interventions
- Drug: Nebivolol
- 10 mg by mouth daily for 2 weeks 20 mg by mouth daily for 2 weeks 40 mg by mouth daily for 2 weeks
- Drug: Metoprolol
- dosage prescribed prior to starting on study
Arms, Groups and Cohorts
- Experimental: Nebivolol
- Nebivolol therapy for 2-6 weeks depending on blood pressure readings
- Experimental: Metoprolol
- Metoprolol therapy for 2-6 weeks depending on blood pressure readings
Clinical Trial Outcome Measures
Primary Measures
- Stable blood pressure
- Time Frame: 6 months
- Subjects will be randomized to nebivolol or metoprolol. Their medication will be titrated so that their blood pressure is within 10% of their initial reading.
Participating in This Clinical Trial
Inclusion Criteria
- Subjects with history of hypertension – Subjects who have received metoprolol for a minimum of 3 months Exclusion Criteria:
- Patients who have had an acute myocardial infarction, coronary revascularization or who have been hospitalized for heart failure or cardiac arrhythmia in the past 6 months
Gender Eligibility: All
Minimum Age: 45 Years
Maximum Age: 75 Years
Are Healthy Volunteers Accepted: No
Investigator Details
- Lead Sponsor
- Creighton University
- Provider of Information About this Clinical Study
- Jennifer Campbell, PharmD, Creighton University
- Overall Official(s)
- Jennifer Campbell, PharmD, Principal Investigator, Creighton University
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