Impact of Nebivolol on Central Aortic Pressure

Overview

A randomized, cross-over, single-blind study to compare the effects of nebivolol and metoprolol on central aortic pressure and peripheral brachial pressure in patients with stable cardiovascular disease.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Crossover Assignment
    • Primary Purpose: Treatment
    • Masking: Single (Investigator)
  • Study Primary Completion Date: May 2010

Interventions

  • Drug: Nebivolol
    • 10 mg by mouth daily for 2 weeks 20 mg by mouth daily for 2 weeks 40 mg by mouth daily for 2 weeks
  • Drug: Metoprolol
    • dosage prescribed prior to starting on study

Arms, Groups and Cohorts

  • Experimental: Nebivolol
    • Nebivolol therapy for 2-6 weeks depending on blood pressure readings
  • Experimental: Metoprolol
    • Metoprolol therapy for 2-6 weeks depending on blood pressure readings

Clinical Trial Outcome Measures

Primary Measures

  • Stable blood pressure
    • Time Frame: 6 months
    • Subjects will be randomized to nebivolol or metoprolol. Their medication will be titrated so that their blood pressure is within 10% of their initial reading.

Participating in This Clinical Trial

Inclusion Criteria

  • Subjects with history of hypertension – Subjects who have received metoprolol for a minimum of 3 months Exclusion Criteria:

  • Patients who have had an acute myocardial infarction, coronary revascularization or who have been hospitalized for heart failure or cardiac arrhythmia in the past 6 months

Gender Eligibility: All

Minimum Age: 45 Years

Maximum Age: 75 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Creighton University
  • Provider of Information About this Clinical Study
    • Jennifer Campbell, PharmD, Creighton University
  • Overall Official(s)
    • Jennifer Campbell, PharmD, Principal Investigator, Creighton University

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