Botulinum Toxin Injection Efficiency

Overview

The purpose of the study is to examine the effect of the botulinum toxin injection into muscle tone, strength and mobility with and without muscle exercise effect.

Full Title of Study: “Effectiveness of Botulinum Toxin Injection After Exercising Splenius Capitis Muscle in Patients With Cervical Dystonia”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Crossover Assignment
    • Primary Purpose: Treatment
    • Masking: Triple (Care Provider, Investigator, Outcomes Assessor)
  • Study Primary Completion Date: December 2009

Detailed Description

The purpose is also to find out patients subjective symptoms between injections. Hypothesis: Efficiency of the botulinum toxin is more powerful with the muscle exercise before injection.

Interventions

  • Other: Resistance training
    • Neck muscle trainings effect on botulinum toxin efficiency

Arms, Groups and Cohorts

  • Experimental: 1
    • resistance training

Clinical Trial Outcome Measures

Primary Measures

  • Muscle tone in splenius capitis muscle
    • Time Frame: five months

Secondary Measures

  • Pain in the neck
    • Time Frame: five months
  • Mobility in the neck
    • Time Frame: five months
  • Neck muscle strength
    • Time Frame: five months

Participating in This Clinical Trial

Inclusion Criteria

  • Clinical diagnosis of cervical dystonia
  • Spasticity in splenius capitis muscle
  • Regular treatment with botulinum toxin injection

Exclusion Criteria

  • Don't want to take part the Trial
  • Very long distance from home to Jyväskylä Central Hospital

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 80 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Jyväskylä Central Hospital
  • Collaborator
    • Eurostars
  • Provider of Information About this Clinical Study
    • Ylinen Jari, Jyvaskylä Central Hospital
  • Overall Official(s)
    • Jari Ylinen, MD, PhD, Study Director, Senior physician

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