Effect of Mobilization on Acute Postoperative Pain and Nociceptive Function

Overview

Aim of the present study is twofold. – First we want to evaluate the effect of mobilization on acute postoperative pain – Second to test weather chances in pain sensitivity are occurring following surgery and mobilization after total knee arthroplasty

Full Title of Study: “Effect of Mobilization on Acute Postoperative Pain and Nociceptive Function After Total Knee Arthroplasty: A Prospective, Consecutive, Trial”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: June 2010

Detailed Description

Little is known about the effect of mobilization on acute postoperative pain and mobilization induced pain, and if altered pain sensitivity occur under these circumstances. – First we want to evaluate the effect of mobilization on acute postoperative pain using the visual analog scale (VAS) – Second to test weather chances in pain sensitivity are occurring following surgery and mobilization after total knee arthroplasty, using two simple tools, the Pain Matcher and a Pressure Algometer.

Interventions

  • Other: Mobilization (walking)
    • 25 meters twice

Clinical Trial Outcome Measures

Primary Measures

  • Pain score on the visual analog scale (difference before and after two mobilisation seances)
    • Time Frame: up to 24 hours
    • pain at rest (supine) 5 min after exercise(after the 2nd walk)

Secondary Measures

  • Pain score on the visual analog scale (difference before and after two mobilisation seances)
    • Time Frame: up to 24 hours
    • pain at rest (supine) 20 min after the 2nd walk, pain during passive hip flexion and pain during passive knee flexion 5 and 20 min after the 2nd walk, as well as pain during the 2nd walk after 6 and 25 m
  • Pain sensitivity measured with pressure algometry and with pain matcher (difference before and after two mobilisation seances and difference before and after surgery)
    • Time Frame: up to 24 hours
    • Nociceptive function before and after postoperative exercise

Participating in This Clinical Trial

Inclusion Criteria

  • Patients scheduled for total unilateral knee arthroplasty Exclusion Criteria:

  • Cognitive dysfunction or peripheral / central neurological dysfunction inconsistent with protocol completing – Alcohol and medical abuse (as defined by the National Health Service of Denmark – Daily use of opioids or glucocorticoids

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Hvidovre University Hospital
  • Collaborator
    • Lundbeck Foundation
  • Provider of Information About this Clinical Study
    • Principal Investigator: Troels Haxholdt Lunn, MD – Hvidovre University Hospital
  • Overall Official(s)
    • Troels Haxholdt Lunn, MD, Principal Investigator, Hvidovre University Hospital

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