Identifying Changes in Blood (Potential Biomarkers) in Individuals With Drug-Induced Liver Injury

Overview

The purpose of this study is to try to develop new blood tests that may help doctors identify if a drug is hurting a person's liver.

Full Title of Study: “Identification of New Biomarkers of Drug Induced Liver Injury”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: December 2013

Detailed Description

Our hypothesis is that there are liver-specific particles, called mRNA, that are identifiable in a person's blood sample during liver injury caused by some drugs. The purpose of this study is to try to develop new blood tests that may help doctors identify if a drug is hurting a person's liver, perhaps early in the process before significant injury or illness have occurred.

Arms, Groups and Cohorts

  • Acute drug-induced liver injury

Participating in This Clinical Trial

Inclusion Criteria

  • ALT > 200 IU/L at presentation to UNC Hospitals
  • Drug induced liver injury considered likely by admitting medical staff

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 80 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • University of North Carolina, Chapel Hill
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Paul B Watkins, MD, Principal Investigator, University of North Carolina, Chapel Hill

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