Assess the Effect of Erythromycin on the Rate of Success in Placement of a Self-propelled Feeding Tube

Overview

The purpose of this study is to assess the effect of erythromycin on the Rate of Success in Placement of a Self-propelled Feeding Tube.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Treatment
    • Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
  • Study Primary Completion Date: July 2007

Interventions

  • Drug: Erythromycin
    • Subjects receive 4x250mg erythromycin i.v. daily after intubation of a self-propelled feeding tube
  • Drug: Placebo
    • Subjects receive 4x placebo i.v. daily after intubation of a self-propelled feeding tube

Arms, Groups and Cohorts

  • Experimental: Erythromycin
  • Placebo Comparator: Placebo

Clinical Trial Outcome Measures

Primary Measures

  • The success rate of spontaneous positioning the tubes tip into the jejunum, beyond Treitz ligament, after 48 hours.

Secondary Measures

  • The success rate of spontaneous positioning the tubes tip into the jejunum, beyond Treitz ligament, after 24 hours.
  • Adverse events using this self-propelled tube

Participating in This Clinical Trial

Inclusion Criteria

  • Aged 18-80 years
  • Having pancreatitis
  • Require jejunal enteral nutrition

Exclusion Criteria

  • Known impaired peristalsis (critically ill patients, postoperative patients, history of surgery of the stomach/duodenum)
  • Pregnancy
  • Hypersensibility to erythromycin
  • Cardiac arrhythmias with a prolonged QT-time
  • Simultaneous usage of drugs impairing peristalsis

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 80 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Canisius-Wilhelmina Hospital

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