Alcohol Exposure and Airway Hyperresponsiveness

Overview

Alcohol has consequences including increased risk for upper respiratory tract infections, pneumonia, acute respiratory distress syndrome (ARDS), and alcohol-induced asthma. The investigators have established that airways are specifically impacted by alcohol exposure because the airways are heavily exposed to the vapor phase of alcohol during drinking. These preliminary studies demonstrate that brief alcohol administration significantly attenuates airway hyperresponsiveness (AHR) in a mouse model leading to the hypothesis that alcohol exposure modifies airway hyperresponsiveness through a cAMP/NO- dependent mechanism.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: N/A
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Basic Science
    • Masking: None (Open Label)
  • Study Primary Completion Date: January 16, 2013

Detailed Description

Alcohol has well-established consequences in the lung including increased risk for upper respiratory tract infections, pneumonia and acute respiratory distress syndrome (ARDS). There have even been a few reports of alcohol-induced asthma. Data from the investigators' laboratory have established that the airways are specifically impacted by alcohol exposure. Because the airways are heavily exposed to the vapor phase of alcohol during drinking and airway motor tone is modulated by cAMP, the investigators speculated that airway bronchial motor function would be altered in mice fed alcohol. The investigators' preliminary studies demonstrate that brief alcohol administration significantly attenuates airway hyperresponsiveness (AHR) in a mouse model. This novel finding has led us to hypothesize that: Alcohol exposure modifies airway hyperresponsiveness through a cAMP/NO- dependent mechanism.

Interventions

  • Other: ethanol
    • subjects will ingest 3 ounces of vodka mixed with fruit juice within 30 min.

Arms, Groups and Cohorts

  • Experimental: Post-alcohol change in airway hyperresponsiveness.
    • Participants will ingest 3 ounces of vodka mixed with fruit juice within 30 min. Then provocative concentration causing a 20% fall in forced expiratory volume in 1 s (PC20FEV1) will be measured. A one-half concentration difference in the PC20FEV1 will be considered a statistically significant change in airway hyperresponsiveness.

Clinical Trial Outcome Measures

Primary Measures

  • Change in airway hyperresponsiveness.
    • Time Frame: 2 hours
    • A one-half concentration difference in the PC20FEV1 will be considered a statistically significant change in airway hyperresponsiveness.

Participating in This Clinical Trial

Inclusion Criteria

  • male – must be of legal drinking age in the state of Nebraska (≥ 21) – be between the ages of 21-65 – be non-smokers – be able to dedicate 3-4 hours on two consecutive days (including waiting at least 2 hours after the alcohol ingestion) – able to provide informed consent Exclusion Criteria:

  • female – inability to give informed consent – any history of lung or allergic disease – any alcohol intake for the week prior to the experiment – self-identified history of chronic heavy drinking or alcoholism or psychiatric disorder – If an otherwise qualifying participant has previously undocumented or unidentified asthma as indicated by the baseline methacholine challenge, that subject will be excluded from the remainder of the study and replaced by another subject

Gender Eligibility: Male

Minimum Age: 21 Years

Maximum Age: 65 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • University of Nebraska
  • Collaborator
    • National Institute on Alcohol Abuse and Alcoholism (NIAAA)
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Joseph H Sisson, MD, Study Director, University of Nebraska

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