Inappropriate Medications Associated With Anticholinesterase and/or Memantine Treatment in the Elderly


In each of the 7 French areas that should be involved, patients aged 75 years and over from three different sectors will be included: the geriatric consultation unit (60%) and two kinds of nursing homes, private (20%) and state (10%). Outpatients will be included in chronological order; patients in nursing homes will be included at random. The patients and their families will be asked about the treatments received on the day of inclusion. The inclusion period will extend over a year. The investigating practitioners will be asked to fill in a questionnaire reporting the main clinical data, adverse effects occurrence, and information on the treatment given.

Full Title of Study: “Inappropriate Medications and Alzheimer Disease: Prevalence and Associated Factors in Elderly Patients Treated With Anticholinesterase and/or Memantine. MIDA Study.”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: July 2011

Clinical Trial Outcome Measures

Primary Measures

  • To evaluate the prevalence of PIM use in patients aged 75 years and over treated with anticholinesterase and/or memantine
    • Time Frame: 2 years

Secondary Measures

  • To identify factors associated with PIM use. To study the relationship between PIM exposure and adverse effects occurrence.
    • Time Frame: 2 years

Participating in This Clinical Trial

Inclusion Criteria

  • Patients aged 75 years and over identified as having Alzheimer disease and who have been treated for more than 3 months with anticholinesterase and/or memantine Exclusion Criteria:
  • Patients with decompensated chronic condition or acute phase disease
  • Gender Eligibility: All

    Minimum Age: 75 Years

    Maximum Age: N/A

    Are Healthy Volunteers Accepted: No

    Investigator Details

    • Lead Sponsor
      • University Hospital, Limoges
    • Provider of Information About this Clinical Study
      • Sponsor

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