Effects of Oxybutynin Topical Gel on Gastric Emptying


This study explores the effect of oxybutynin topical gel on gastric emptying

Full Title of Study: “Effect of Oxybutynin Chloride Topical Gel on Gastric Emptying, Using the Acetaminophen Absorption Test”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Crossover Assignment
    • Primary Purpose: Basic Science
    • Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
  • Study Primary Completion Date: July 2009


  • Drug: Oxybutynin Chloride Gel
    • Once daily for 7 days, followed by single dose of acetaminophen
  • Drug: Placebo Gel
    • Once daily for 7 days, followed by single dose of acetaminophen

Arms, Groups and Cohorts

  • Experimental: Active OTG
  • Placebo Comparator: Placebo

Clinical Trial Outcome Measures

Primary Measures

  • The effect of oxybutynin chloride topical gel administration on gastric emptying will be assessed by comparing the single dose relative bioavailability of acetaminophen
    • Time Frame: After 7 days of treatment

Participating in This Clinical Trial

Inclusion Criteria

  • Adult, healthy, post-menopausal females Exclusion Criteria:

  • Patients for whom OTG or acetaminophen is contraindicated. – Abnormality of the GI tract. – Taking drugs that affect gastric motility.

Gender Eligibility: Female

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Watson Pharmaceuticals
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Scott Olsen, MPH, Study Director, Watson Laboratories

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