Posterior Macular Adhesion: A Potential Risk Factor for Non-exudative Age Related Macular Degeneration (AMD) to Develop Exudative AMD

Overview

Choroidal neovascularisation in age related macular degeneration is one of the major causes of legal blindness in the western world existing in two major occurences, the dry and the wet form.The etiology of age related macular degeneration is yet unknown. Genetic factors, oxidative stress, Ischaemia, and aging of the retinal pigment epithelium are discussed as etiologic factors. The risk of rapid vision loss is much higher in wet AMD, a dry form may transform to a wet form. From a prior study the investigators know that the posterior hyaloid is significantly more frequent attached in wet AMD. This study is conducted to examine whether the attached posterior hyaloid is a risk factor to develop wet AMD in dry AMD cases.

Full Title of Study: “Posterior Macular Adhesion: A Potential Risk Factor for Non-exudative AMD to Develop Exudative AMD”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: December 2012

Interventions

  • Device: ultrasound
    • A-scan and B-scan ultrasound at baseline and month 6,12,24
  • Device: OCT
    • Volume scans of spectralis OCT at baseline and month 6,12,24

Arms, Groups and Cohorts

  • Dry AMD
    • male or female persons aged over 50 years with dry age-related macular degeneration

Clinical Trial Outcome Measures

Primary Measures

  • Number of eyes with non-exudative AMD with attached and detached posterior vitreous cortex developing exudative AMD
    • Time Frame: 24 months

Secondary Measures

  • Distance acuity
    • Time Frame: 24 months
  • Age
    • Time Frame: 24 months
  • Smoking
    • Time Frame: 24 months
  • Obesity
    • Time Frame: 24 months
  • Lesion classification (AREDS)
    • Time Frame: 24 months

Participating in This Clinical Trial

Inclusion Criteria

  • Dry MD – Age over 50 years Exclusion Criteria:

  • Macular pathologies other than age related macular degeneration (like diabetic maculopathy, macular pucker, macular hole) – Prior vitrectomy or buckle surgery – Uveitis posterior, multifocal chorioiditis – Pathologic myopia – Diabetic retinopathy – Visualization of the macula not possible (dens cataract, vitreous haemorrhage)

Gender Eligibility: All

Minimum Age: 50 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery
  • Provider of Information About this Clinical Study
    • Ilse Krebs,MD, The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery
  • Overall Official(s)
    • Susanne Binder, Prof MD, Study Chair, Ludwig Boltzmann Institute for Retinology and Biomicroscopic Laser Surgery
  • Overall Contact(s)
    • Ilse Krebs, MD, +43171165, ilse.krebs@wienkav.at

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