Developing Mouse Models of Breast Cancer Using Tissue Samples From Women With Breast Cancer

Overview

RATIONALE: Changing the genes in laboratory mice to create a living model of human breast cancer may help doctors learn more about breast cancer. PURPOSE: This research study is developing mouse models of breast cancer using tissue samples that were previously collected from women with breast cancer.

Full Title of Study: “Developing In-Vivo Models of Human Breast Cancer”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: May 2018

Detailed Description

OBJECTIVES: – To develop new in vivo models of human breast cancer. – To correlate response in this model to actual treatment outcome in patients, if the in vivo model is proven feasible. OUTLINE: Previously collected breast tumor fragments are implanted into the renal capsule site of SCID mouse hosts (mouse with severe combined immune deficiency) to establish metastatic spread patterns, and both histologic and molecular tumor characteristics. Patients' medical charts are reviewed to obtain relevant information, including general demographics, smoking and alcohol use, as well as outcome data such as survival and response to treatment.

Interventions

  • Other: laboratory biomarker analysis
    • Tissue samples will either be collected at the time of medically indicated surgical procedures or through research core biopsies. A sample of urine will also be obtained. Blood will be collected via venipuncture and lymphocytes (mononuclear cells) separated and processed as a source of normal DNA and normal cells.
  • Other: medical chart review
    • patient chart review will occur in conjunction with patient data collection for final analyses.

Arms, Groups and Cohorts

  • breast cancer patients

Clinical Trial Outcome Measures

Primary Measures

  • Development of new in vivo models of human breast cancer
    • Time Frame: 1 year
  • Correlation of response in this model to actual treatment outcome in patients, if the in vivo model proven feasible
    • Time Frame: 5 years

Participating in This Clinical Trial

DISEASE CHARACTERISTICS:

  • Diagnosis of breast cancer – Any stage of disease – Primary or metastatic disease – Human breast tumor tissues available after the diagnoses have been made – Enrolled on the ongoing Breast Tissue Repository trial VU-VICC-BRE-03103 – Have consented to the use of their tissues for research purpose – Hormone receptor status not specified PATIENT CHARACTERISTICS: – Menopausal status not specified PRIOR CONCURRENT THERAPY: – Not specified

Gender Eligibility: Female

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Vanderbilt-Ingram Cancer Center
  • Collaborator
    • National Cancer Institute (NCI)
  • Provider of Information About this Clinical Study
    • Principal Investigator: A Bapsi Chakravarthy, MD, Associate Professor; Radiation Oncologist – Vanderbilt-Ingram Cancer Center
  • Overall Official(s)
    • A. Bapsi Chakravarthy, MD, Principal Investigator, Vanderbilt-Ingram Cancer Center

Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.

At TrialBulletin.com, we keep tabs on over 200,000 clinical trials in the US and abroad, using medical data supplied directly by the US National Institutes of Health. Please see the About and Contact page for details.