Influence of Corticoids on Renal Function in Cardiac Surgery

Overview

Hypothesis: Corticoid treatment in cardiac surgery works renal protective. Study design: Randomized, double blind trial in which one group of patients will receive methylprednisolone and the other group (control) will receive placebo NaCl 0.9%.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Treatment
    • Masking: Double (Participant, Investigator)
  • Study Primary Completion Date: July 2015

Interventions

  • Drug: Methylprednisolone
    • Methylprednisolone
  • Drug: Placebo
    • Placebo (NaCl 0.9%)

Arms, Groups and Cohorts

  • Experimental: 1
    • methylprednisolone
  • Placebo Comparator: 2
    • Placebo (NaCl 0.9%)

Clinical Trial Outcome Measures

Primary Measures

  • Renal dysfunction and renal failure postoperatively in cardiac surgery
    • Time Frame: within 48 hours after cardiac surgery

Participating in This Clinical Trial

Inclusion Criteria

  • age between 20-80 year – patients scheduled for elective cardiac surgery. – preoperative creatinine levels of < 2mg/dl – no corticoid treatment Exclusion Criteria:

  • non-elective surgery – patiënts with renal dysfunction: creatinine > 2mg/dl – patiënts treated with corticoids

Gender Eligibility: All

Minimum Age: 20 Years

Maximum Age: 80 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • University Hospital, Ghent
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Stefaan Bouchez, MD, Principal Investigator, University Hospital, Ghent

Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.

At TrialBulletin.com, we keep tabs on over 200,000 clinical trials in the US and abroad, using medical data supplied directly by the US National Institutes of Health. Please see the About and Contact page for details.