The Effect of Chloroquine in the Treatment of Patients With Dengue
Overview
The objective of this study was to evaluate the effect of chloroquine in the treatment of patients with dengue.
Study Type
- Study Type: Interventional
- Study Design
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Primary Purpose: Treatment
- Masking: Double (Participant, Investigator)
- Study Primary Completion Date: May 2008
Interventions
- Drug: Placebo
- Placebo bid for three days
- Drug: Chloroquine
- Chloroquine bid for three days
Arms, Groups and Cohorts
- Placebo Comparator: 1
- Active Comparator: 2
Clinical Trial Outcome Measures
Primary Measures
- Duration of the disease
- Time Frame: one week
Secondary Measures
- Intensity and days of fever and symptoms
- Time Frame: one week
Participating in This Clinical Trial
Inclusion Criteria
- Patients suspected of having dengue disease – Patients were included in the study if they presented with fever and at least two other symptoms, such as: – headache – pain behind the eyes – muscle and bone or joint pains – nausea – vomiting – rash associated to dengue for less than 72 hours Exclusion Criteria:
- Pregnant – Younger than 18-years old – Either cardiac or neurologic disease
Gender Eligibility: All
Minimum Age: 18 Years
Maximum Age: N/A
Are Healthy Volunteers Accepted: No
Investigator Details
- Lead Sponsor
- University of Sao Paulo
- Collaborator
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Provider of Information About this Clinical Study
- Benedito Antonio Lopes da Fonseca, São Paulo University Medical School at Ribeirão Preto
- Overall Official(s)
- Benedito AL Fonseca, PhD, Principal Investigator, São Paulo University Medical School at Ribeirão Preto
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