Acute Effects of Glucose Dependent Insulinotropic Polypeptide (GIP) on Subcutaneous Adipose Tissue

Overview

This clinical, randomized, cross-over study in obese healthy subjects aimed to analyse the acute effects of the incretin hormon Glucose Dependent Insulinotropic Polypeptide (GIP) on metabolic parameters and gene expression in subcutaneous adipose tissue.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Crossover Assignment
    • Primary Purpose: Basic Science
    • Masking: Single (Participant)
  • Study Primary Completion Date: July 2007

Interventions

  • Other: Glucose dependent insulinotropic polypeptide (GIP)
    • GIP-Infusions for 4 h in a postprandial concentration

Clinical Trial Outcome Measures

Primary Measures

  • Changes in gene expression of subcutaneous adipose tissue with microarray analysis
    • Time Frame: 3 years

Secondary Measures

  • Analysis of inflammatory marker (blood levels and gene expression), Activity of 11beta HSD and 11-beta HSD mRNA in adipose tissue, etc.
    • Time Frame: 3 years

Participating in This Clinical Trial

Inclusion Criteria

  • BMI > 28 – Healthy subjects – Normal glucose tolerance Exclusion Criteria:

  • Diabetes,IFG, IGT – Chronical-inflammatory diseases – Hb < 12g/dl – Elevation in liver enzymes or creatinin concentrations – Great weight changes within last 12 months – Any cancer diagnosis in last 10 years

Gender Eligibility: Male

Minimum Age: 18 Years

Maximum Age: 70 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • German Institute of Human Nutrition
  • Collaborator
    • German Research Foundation
  • Provider of Information About this Clinical Study
    • AFH. Pfeiffer, German Institute of Human Nutrition

Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.

At TrialBulletin.com, we keep tabs on over 200,000 clinical trials in the US and abroad, using medical data supplied directly by the US National Institutes of Health. Please see the About and Contact page for details.