Acute Effects of Glucose Dependent Insulinotropic Polypeptide (GIP) on Subcutaneous Adipose Tissue
Overview
This clinical, randomized, cross-over study in obese healthy subjects aimed to analyse the acute effects of the incretin hormon Glucose Dependent Insulinotropic Polypeptide (GIP) on metabolic parameters and gene expression in subcutaneous adipose tissue.
Study Type
- Study Type: Interventional
- Study Design
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Primary Purpose: Basic Science
- Masking: Single (Participant)
- Study Primary Completion Date: July 2007
Interventions
- Other: Glucose dependent insulinotropic polypeptide (GIP)
- GIP-Infusions for 4 h in a postprandial concentration
Clinical Trial Outcome Measures
Primary Measures
- Changes in gene expression of subcutaneous adipose tissue with microarray analysis
- Time Frame: 3 years
Secondary Measures
- Analysis of inflammatory marker (blood levels and gene expression), Activity of 11beta HSD and 11-beta HSD mRNA in adipose tissue, etc.
- Time Frame: 3 years
Participating in This Clinical Trial
Inclusion Criteria
- BMI > 28 – Healthy subjects – Normal glucose tolerance Exclusion Criteria:
- Diabetes,IFG, IGT – Chronical-inflammatory diseases – Hb < 12g/dl – Elevation in liver enzymes or creatinin concentrations – Great weight changes within last 12 months – Any cancer diagnosis in last 10 years
Gender Eligibility: Male
Minimum Age: 18 Years
Maximum Age: 70 Years
Are Healthy Volunteers Accepted: Accepts Healthy Volunteers
Investigator Details
- Lead Sponsor
- German Institute of Human Nutrition
- Collaborator
- German Research Foundation
- Provider of Information About this Clinical Study
- AFH. Pfeiffer, German Institute of Human Nutrition
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