Insulin Sensitivity and Metabolism Before and After Treatment in Patients With Hypothyroidism

Overview

The aim of this study is to further characterize the treatment related changes in insulin sensitivity, substrate metabolism and intra hepatic- and intramyocellular lipid content in patients with hypothyroidism

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: N/A
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Basic Science
    • Masking: None (Open Label)
  • Study Primary Completion Date: January 2010

Interventions

  • Drug: Levothyroxin
    • Dosage regulation will follow the local recommendations of treatment

Arms, Groups and Cohorts

  • Experimental: 1
    • the aim of the present study is to characterize the treatment related changes in insulin sensitivity, substrate metabolism and intrahepatic – intramyocellular lipids in 12 adult patients, recently diagnosed with hypothyroidism

Clinical Trial Outcome Measures

Primary Measures

  • intracellular lipid content in liver and muscle
    • Time Frame: before and after 3 months treatment with growth hormone
  • intraabdominal lipid content
    • Time Frame: before and after treatment
  • insulin sensitivity
    • Time Frame: before and after treatment
  • substrate metabolism
    • Time Frame: before and after treatment
  • intracellular signaling in the basal state and during insulin stimulation
    • Time Frame: before and after treatment

Participating in This Clinical Trial

Inclusion Criteria

  • written informed consent – must be of legal age and competent – Age > 18 years – presently diagnosed with hypothyroidism Exclusion Criteria:

  • alcohol consumption >21 units per week – Malignant disease – pregnancy – magnetic implants or material in the body – BMI > 30 – Heart disease (NYHA >2) – Uncontrolled hypertension – Manifest diabetes mellitus – Changes in medication, with any influence on glucose metabolism, 2 months prior to and until the end of the trial.

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • University of Aarhus
  • Collaborator
    • MR Research Center, Skejby Sygehus, Brendstrupgaardsvej 100, 8200 Aarhus N
  • Provider of Information About this Clinical Study
    • Jens Otto Lunde Jorgensen, Medical Department M, Aarhus University Hospital, Aarhus Sygehus, Norrebrogade 44, 8000 Aarhus C

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