Surgical Treatment of Hilar Cholangiocarcinoma: Minor or Major Liver Resection?

Overview

The investigators conducted a prospective study to determine the safety and efficacy of minor and major hepatectomy selected by predetermined criteria in 138 patients with hilar cholangiocarcinoma. In selected patients, minor liver resection was a good treatment.

Study Type

  • Study Type: Interventional

Detailed Description

Objective: To determine the safety and efficacy of minor and major hepatectomy selected by predetermined criteria in patients with hilar cholangiocarcinoma (HC).

Summary Background Data: For HC treated with hepatectomy, the extent of liver resection remains controversial despite extensive studies.

Methods: From January 2000 to December 2007, we prospectively studied patients who received surgical treatment for HC. Of the 187 patients who were surgically treated, 138 (73.8%) underwent resection with a curative intent. Minor hepatectomy was carried out in 93 patients who had Bismuth-Corlette types I, II and III HC without hepatic artery/portal vein invasion; and major hepatectomy in 45 patients who had type III HC with hepatic artery/portal vein invasion, or type IV HC.

Interventions

  • Procedure: Minor or Major Liver Resection

Arms, Groups and Cohorts

  • No Intervention: Control group

Clinical Trial Outcome Measures

Primary Measures

  • On multivariate analysis, prognostic factors significantly impacted on long-term survival were UICC tumor stage and histopathologic grade.

Participating in This Clinical Trial

Inclusion Criteria

  • Criteria for resectability were absence of peritoneal or liver metastases, tumor extension to beyond secondary biliary branches bilaterally, tumor extension to secondary portal venous branches bilaterally

Exclusion Criteria

  • not in accordance with the above criteria

Gender Eligibility: All

Minimum Age: 26 Years

Maximum Age: 72 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Huazhong University of Science and Technology
  • Collaborator
    • Ministry of Health, China

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