Clonidine-Remifentanil. Effect of the Combination on Acute Pain and Respiration in Healthy Volunteers
Overview
The hypothesis is that systemic remifentanil and Clonidine act in a synergistic manner to relief acute main in an experimental human pain model. Of interest is also the effect of the combination on respiration, sedation and cognitive behavior.
Study Type
- Study Type: Interventional
- Study Design
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Primary Purpose: Treatment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Study Primary Completion Date: May 2005
Detailed Description
To examine the possible synergistic effects og systemic remifentanil and clonidine. Its effects on respiration, cognitive function and sedation.
Interventions
- Drug: Remifentanil+clonidine
- iv Remifentanil+ iv clonidine
Arms, Groups and Cohorts
- Active Comparator: 1
- Clonidine
- Active Comparator: 2
- Remifentanil
- Experimental: 4
- Remifentanil+clonidine
- Placebo Comparator: 3
- Placebo
Clinical Trial Outcome Measures
Primary Measures
- Relief of pain(VAS reduction)
- Time Frame: Experimental
Secondary Measures
- Reduction in Minute ventilation
- Time Frame: Experimental
- Reduction in CO2 stimulated Minute Ventilation
- Time Frame: experimental
- Reduction in BIS score
- Time Frame: Experimental
- Performance on Stroop test
- Time Frame: Experimental
Participating in This Clinical Trial
Inclusion Criteria
- Healthy volunteers Exclusion Criteria:
-
Gender Eligibility: All
Minimum Age: 18 Years
Maximum Age: 50 Years
Are Healthy Volunteers Accepted: Accepts Healthy Volunteers
Investigator Details
- Lead Sponsor
- Oslo University Hospital
- Provider of Information About this Clinical Study
- Dr. Jon Bragi Bergmann, Dep.of anasthesiology, Rikshospitalet, Oslo, Norway
- Overall Official(s)
- Jon B Bergmann, Ass. Prof., Principal Investigator, Dep of Anesthesia and Intensive Care, Rikshospitalet-Radiumhospitalet Medical Center
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