Granuloma Annulare Treated With Rifampin, Ofloxacin, and Minocycline Combination Therapy

Overview

Granuloma annulare is a benign, usually self-limiting, cutaneous dermatosis, which typically presents as asymptomatic, flesh-colored or red papules, frequently arranged in an annular pattern on the distal extremities. Although localized granuloma annulare is most commonly observed, a generalized or disseminated form can occur. The etiology of granuloma annulare is unknown, however, multiple inciting factors have been proposed. The purpose of the investigators is to review the outcomes of treatment of granuloma annulare (GA) resistant to standard regimens that resolved after a 3-months treatment course of monthly rifampin, ofloxacin, and minocycline (ROM) therapy, successfully used to treat paucibacillary leprosy, a disease with clinical and histopathologic similarity to GA.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Retrospective
  • Study Primary Completion Date: May 2008

Detailed Description

We will document the regimen treatment each patient has had and then review the following from the patient's chart to target our specific aims as outlined above. 1. What previous treatment options have been or/are currently being used? 2. How long did the patient take the treatment for? 3. Was the patient able to discontinue or become less dependent on prior treatment? 4. Was the disease process slowed by the treatment?; 5. Were there any side effects that the patient experienced with treatment?

Participating in This Clinical Trial

Inclusion Criteria

  • Patients with granuloma annulare who are resistent to the standard treatment. Exclusion Criteria:

  • Response to the standard treatment of granuloma annulare.

Gender Eligibility: All

Minimum Age: N/A

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Henry Ford Health System
  • Provider of Information About this Clinical Study
    • Iltefat H. Hamzavi, MD, Henry Ford Health System
  • Overall Official(s)
    • Iltefat H Hamzavi, MD, Principal Investigator, Henry Ford Health System

References

Duarte AF, Mota A, Pereira MA, Baudrier T, Azevedo F. Generalized granuloma annulare–response to doxycycline. J Eur Acad Dermatol Venereol. 2009 Jan;23(1):84-5. doi: 10.1111/j.1468-3083.2008.02707.x. Epub 2008 Apr 1. No abstract available.

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