Mitral Valve Area Assessment: Comparison With Transthoracic Echocardiography and Magnetic Resonance Imaging

Overview

To compare mitral valve area in rheumatic mitral valve stenosis with cardiac magnetic resonance imaging and conventional transthoracic echocardiography.

Full Title of Study: “Quantification of Rheumatic Mitral Stenosis With Cardiac Magnetic Resonance Imaging and Comparison With Transthoracic Echocardiography”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: June 2008

Detailed Description

Clinical assessment of severity of mitral stenosis depends on both the presence of symptoms and mitral valve area . Evaluation of mitral valve area with transthoracic echocardiography maintains rapid, accurate analysis of valve disease and serves as a practical gold standard for clinical evaluation. Cardiac magnetic resonance imaging (CMRI) is a recently used method that allows to evaluate cardiac structures and function noninvasively. Direct visualization of valve area with CMRI is also possible and it has been shown that the valve area assessed by CMRI planimetry correlates reliably with the invasive assessment. Velocity-encoded cardiac magnetic resonance imaging can be used to quantify mitral valve area. The objective of this study was to evaluate mitral valve area with CMRI and compare it with echocardiographic methods including 2D planimetry, Doppler continuation equation and Doppler pressure half-time

Arms, Groups and Cohorts

  • A
    • Mitral valve area above 1.5 cm2
  • B
    • Mitral valve area 1.5 cm2 and below 1.5 cm2

Participating in This Clinical Trial

Inclusion Criteria

  • rheumatic mitral valve stenosis Exclusion Criteria:

  • Degenerative mitral valve disease – EF<50% – atrial fibrillation – inconclusive planimetric assessment – moderate or severe mitral regurgitation – moderate or severe aortic regurgitation – history of previous mitral valve commissurotomy or balloon valvotomy

Gender Eligibility: All

Minimum Age: 20 Years

Maximum Age: 65 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Florence Nightingale Hospital, Istanbul
  • Provider of Information About this Clinical Study
    • Prof. Dr. Saide Aytekin, T.C. Istanbul Bilim University, Florence Nightingale Hospital
  • Overall Official(s)
    • Saide Aytekin, Professor, Study Director, T.C. Istanbul Bilim University, Florence Nightingale Hospital, Division of Cardiology
  • Overall Contact(s)
    • Saide Aytekin, Professor, 00902122244950, saideaytekin@gmail.com

References

Lin SJ, Brown PA, Watkins MP, Williams TA, Lehr KA, Liu W, Lanza GM, Wickline SA, Caruthers SD. Quantification of stenotic mitral valve area with magnetic resonance imaging and comparison with Doppler ultrasound. J Am Coll Cardiol. 2004 Jul 7;44(1):133-7. doi: 10.1016/j.jacc.2004.03.038.

Djavidani B, Debl K, Lenhart M, Seitz J, Paetzel C, Schmid FX, Nitz WR, Feuerbach S, Riegger G, Luchner A. Planimetry of mitral valve stenosis by magnetic resonance imaging. J Am Coll Cardiol. 2005 Jun 21;45(12):2048-53. doi: 10.1016/j.jacc.2005.03.036.

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