Substrate Metabolism and Insulin Sensitivity in Acromegalic Patients Before and After Treatment

Overview

The purpose of this study is to investigate the effects of chronic elevated growth hormone on metabolism and insulin sensitivity by studying acromegalic patients before and after treatment.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: December 7, 2016

Interventions

  • Procedure: Transsphenoidal adenomectomy
    • Surgery

Arms, Groups and Cohorts

  • 1
    • Patients recently diagnosed with acromegaly

Clinical Trial Outcome Measures

Primary Measures

  • Insulin sensitivity
    • Time Frame: Before and after treatment

Secondary Measures

  • QoL, body composition, intrahepatic and intramyocellular fat, substrate metabolism, Glucose tolerance
    • Time Frame: Before and after treatment

Participating in This Clinical Trial

Inclusion Criteria

  • Written consent – Age between 18 and 70 – Recently diagnosed with acromegaly Exclusion Criteria:

  • NYHA 3 – Uncontrolled hypertension – Known cerebrovascular disease – Proliferative retinopatia

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 70 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • University of Aarhus
  • Collaborator
    • Aarhus University Hospital
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Jens Otto L. Jørgensen, Professor MD, Principal Investigator, Aarhus University Hospital, Department of Endocrinology

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