Substrate Metabolism and Insulin Sensitivity in Acromegalic Patients Before and After Treatment
Overview
The purpose of this study is to investigate the effects of chronic elevated growth hormone on metabolism and insulin sensitivity by studying acromegalic patients before and after treatment.
Study Type
- Study Type: Observational
- Study Design
- Time Perspective: Prospective
- Study Primary Completion Date: December 7, 2016
Interventions
- Procedure: Transsphenoidal adenomectomy
- Surgery
Arms, Groups and Cohorts
- 1
- Patients recently diagnosed with acromegaly
Clinical Trial Outcome Measures
Primary Measures
- Insulin sensitivity
- Time Frame: Before and after treatment
Secondary Measures
- QoL, body composition, intrahepatic and intramyocellular fat, substrate metabolism, Glucose tolerance
- Time Frame: Before and after treatment
Participating in This Clinical Trial
Inclusion Criteria
- Written consent – Age between 18 and 70 – Recently diagnosed with acromegaly Exclusion Criteria:
- NYHA 3 – Uncontrolled hypertension – Known cerebrovascular disease – Proliferative retinopatia
Gender Eligibility: All
Minimum Age: 18 Years
Maximum Age: 70 Years
Are Healthy Volunteers Accepted: No
Investigator Details
- Lead Sponsor
- University of Aarhus
- Collaborator
- Aarhus University Hospital
- Provider of Information About this Clinical Study
- Sponsor
- Overall Official(s)
- Jens Otto L. Jørgensen, Professor MD, Principal Investigator, Aarhus University Hospital, Department of Endocrinology
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