Labor Analgesia With Ropivacaine and Clonidine
Overview
The aim of the present study was to examine, for pain relief during labor, the efficacy of two pharmacological approaches – the 0.125% ropivacaine alone and the 0.0625% ropivacaine added to 75 ug clonidine, both by epidural administration. The effect of the drugs on mother and newborn was also determined.
Full Title of Study: “Labor Analgesia With Ropivacaine Added to Clonidine. A Randomized Clinical Trial”
Study Type
- Study Type: Observational
- Study Design
- Time Perspective: Prospective
- Study Primary Completion Date: May 2000
Interventions
- Drug: ropivacaine
- 15 ml of ropivacaine 0.125% peridural once
- Drug: ropivacaine and clonidine
- 15 ml of ropivacaine 0.0625% plus 75 mcg clonidine
Arms, Groups and Cohorts
- R
- R group:15 mL of 0.125% ropivacaine (18.75 mg)
- RC
- RC group:0.0625% ropivacaine (9.375 mg) plus 75 ug clonidine
Participating in This Clinical Trial
Inclusion Criteria
- Singleton healthy – Full-term pregnancy – American Society of Anesthesiologists physical status I or II Exclusion Criteria:
- Patients who had received opioids – History of hypersensitivity to local anesthetic or to clonidine – Fetus showed signs of possible intrauterine suffering – Fetus showed signs of possible neurological deficit
Gender Eligibility: All
Minimum Age: N/A
Maximum Age: N/A
Are Healthy Volunteers Accepted: Accepts Healthy Volunteers
Investigator Details
- Lead Sponsor
- UPECLIN HC FM Botucatu Unesp
- Collaborator
- Faculdade de Medicina de Botucatu, UNESP, Botucatu, Brasil
- Provider of Information About this Clinical Study
- Principal Investigator: Yara Marcondes Machado Castiglia, MD PhD – UPECLIN HC FM Botucatu Unesp
- Overall Official(s)
- Giane Nakamura, MD PHd, Principal Investigator, College Study of Medicine
Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.