Labor Analgesia With Ropivacaine and Clonidine

Overview

The aim of the present study was to examine, for pain relief during labor, the efficacy of two pharmacological approaches – the 0.125% ropivacaine alone and the 0.0625% ropivacaine added to 75 ug clonidine, both by epidural administration. The effect of the drugs on mother and newborn was also determined.

Full Title of Study: “Labor Analgesia With Ropivacaine Added to Clonidine. A Randomized Clinical Trial”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: May 2000

Interventions

  • Drug: ropivacaine
    • 15 ml of ropivacaine 0.125% peridural once
  • Drug: ropivacaine and clonidine
    • 15 ml of ropivacaine 0.0625% plus 75 mcg clonidine

Arms, Groups and Cohorts

  • R
    • R group:15 mL of 0.125% ropivacaine (18.75 mg)
  • RC
    • RC group:0.0625% ropivacaine (9.375 mg) plus 75 ug clonidine

Participating in This Clinical Trial

Inclusion Criteria

  • Singleton healthy – Full-term pregnancy – American Society of Anesthesiologists physical status I or II Exclusion Criteria:

  • Patients who had received opioids – History of hypersensitivity to local anesthetic or to clonidine – Fetus showed signs of possible intrauterine suffering – Fetus showed signs of possible neurological deficit

Gender Eligibility: All

Minimum Age: N/A

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • UPECLIN HC FM Botucatu Unesp
  • Collaborator
    • Faculdade de Medicina de Botucatu, UNESP, Botucatu, Brasil
  • Provider of Information About this Clinical Study
    • Principal Investigator: Yara Marcondes Machado Castiglia, MD PhD – UPECLIN HC FM Botucatu Unesp
  • Overall Official(s)
    • Giane Nakamura, MD PHd, Principal Investigator, College Study of Medicine

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