Omega-3 Fatty Acids for Major Depressive Disorder During Pregnancy

Overview

Whether high-dose omega-3 fatty acids supplement would be an effective treatment in patients with major depressive disorder during pregnancy and breast-feeding.

Full Title of Study: “Omega-3 Polyunsaturated Fatty Acids in Women With Major Depressive Disorders During Pregnancy”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Treatment
    • Masking: Double (Participant, Investigator)
  • Study Primary Completion Date: June 2004

Interventions

  • Dietary Supplement: Omega-3 fatty acids

Arms, Groups and Cohorts

  • Experimental: 1
    • omega-3 fatty acid with 2.2 g of eicosapentanoic acid (EPA) and 1.2 g of docosahexanoic acid (DHA)
  • Placebo Comparator: 2
    • Placebo (olive oil ethyl esters)

Participating in This Clinical Trial

Inclusion Criteria

  • Eligible participants were pregnant women, aged 18 to 40 years, with major depressive disorder onset between their 16th week (second trimester) and 32nd week (third trimester) of gestation at the Department of Obstetrics. Exclusion Criteria:

  • Subjects were excluded with a DSM-IV diagnosis of bipolar disorders, psychotic disorders, substance abuse or dependence for at least 3 months, or any Axis-II diagnosis of borderline or antisocial personality disorder.

Gender Eligibility: Female

Minimum Age: 18 Years

Maximum Age: 40 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • National Science Council, Taiwan
  • Provider of Information About this Clinical Study
    • Kuan-Pin Su, China Medical University Hospital

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