Incidence of Ocular Antibodies in Patients With Sturge – Weber Syndrome (SWS)


Sturge-Weber Syndrome (SWS) is a neurological disorder characterized at birth by seizures and a large port-wine stain birthmark on the forehead and upper eyelid of one side of the face. SWS is also accompanied by an increased pressure within the eye (glaucoma) which can develop very early in life. Glaucoma represents a group of ocular disorders that are characterized by the loss of retinal ganglion cells and their axons, damage to the optic nerve, and gradual loss of visual field. Recently, several studies provided evidence that there is a potential role of the immune system in the pathogenesis of glaucoma. These findings suggest that there might be changes in systemic humoral immunity possibly underlying the optic neuropathy in at least some glaucoma patients.

Full Title of Study: “Incidence of Ocular Antibodies in Patients With Sturge – Weber Syndrome (SWS)”

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: July 2007

Detailed Description

The ocular antibody profile in patients with SWS is unknown.The researchers want to study on blood and tear drop samples from patients with SWS to determine the incidence of ocular antibodies in patients with this syndrome.


  • Other: blood sample tear drop sample
    • blood sample tear drop sample

Arms, Groups and Cohorts

  • blood sample tear drop sample
    • blood sample tear drop sample

Participating in This Clinical Trial

Inclusion Criteria

  • Male and female volunteers with SWS of all ages Exclusion Criteria:
  • Volunteers without SWS
  • Gender Eligibility: All

    Minimum Age: N/A

    Maximum Age: N/A

    Are Healthy Volunteers Accepted: No

    Investigator Details

    • Lead Sponsor
      • University of California, Irvine
    • Collaborator
      • Mainz University
    • Provider of Information About this Clinical Study
      • Principal Investigator: Beckman Laser Institute and Medical Center, J.S.Nelson, MD,PhD,Professor of Surgery and Biomedical Engineering – University of California, Irvine
    • Overall Official(s)
      • John S Nelson, M.D,PhD, Principal Investigator, Beckman Laser Institute University of California Irvine

    Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.

    At, we keep tabs on over 200,000 clinical trials in the US and abroad, using medical data supplied directly by the US National Institutes of Health. Please see the About and Contact page for details.