Duration of Protective Effect From Inhaled Ipratropium Bromide on Methacholine Airway Hyperresponsiveness

Overview

Certain lung disease medications can influence diagnostic tests and research investigations. This study will investigate how long ipratropium bromide must be withheld before a methacholine challenge test can be conducted. This information will be useful for validating current guidelines.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Crossover Assignment
    • Primary Purpose: Diagnostic
    • Masking: Triple (Participant, Investigator, Outcomes Assessor)
  • Study Primary Completion Date: April 2008

Interventions

  • Drug: ipratropium bromide
    • 2 puffs (40 micrograms) 2 puffs (0micrograms)
  • Drug: placebo
    • Matched placebo

Arms, Groups and Cohorts

  • Active Comparator: 1
  • Placebo Comparator: 2

Clinical Trial Outcome Measures

Primary Measures

  • methacholine PC20
    • Time Frame: 6hours and 12 hours post inhalation

Participating in This Clinical Trial

Inclusion Criteria

  • Diagnosis of asthma; stable and controlled – FEV1 greater than or equal to 65% predicted Exclusion Criteria:

  • Concomitant lung disease other than asthma

Gender Eligibility: All

Minimum Age: 19 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • University of Saskatchewan
  • Collaborator
    • Royal University Hospital Foundation
  • Provider of Information About this Clinical Study
    • Dr. Donald W. Cockcroft, Department of Medicine, University of Saskatchewan
  • Overall Official(s)
    • Donald W Cockcroft, MD, Principal Investigator, Department of Medicine University of Saskatchewan

Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.

At TrialBulletin.com, we keep tabs on over 200,000 clinical trials in the US and abroad, using medical data supplied directly by the US National Institutes of Health. Please see the About and Contact page for details.