Evaluation of Potential Vitamin D Effects on Muscle: a Pilot Study

Overview

People who do not have adequate amounts of vitamin D develop weakness of leg and arm muscles. This study will determine if vitamin D supplementation benefits muscle functions important for swallowing, bladder and bowel function.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Non-Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Treatment
    • Masking: Double (Participant, Investigator)
  • Study Primary Completion Date: May 2010

Interventions

  • Other: Ergocalciferol (vitamin D2)
    • 50,000 IU 3 times weekly for 4 weeks

Arms, Groups and Cohorts

  • Placebo Comparator: 1
    • oral placebo 3 times weekly

Clinical Trial Outcome Measures

Primary Measures

  • change in lingual strength and perceived swallow function
    • Time Frame: 4 weeks

Secondary Measures

  • change in perceived bowel and bladder function
    • Time Frame: 4 weeks

Participating in This Clinical Trial

Inclusion Criteria

  • Patients who present for evaluation to the UW Geriatric clinic including Dr. Pryzbelski's subspecialty, or Osteoporosis clinics – Age 70 years or older – Cognitively intact, as determined by the attending physicians at above mentioned clinics Exclusion Criteria:

  • History of, on ongoing, renal failure – History of liver failure – Known malabsorption – Known disorders of parathyroid function, hyper/hypocalcemia, or other abnormalities of calcium or phosphate metabolism – Known history of vitamin D intoxication or granulomatous disease – active seizure disorder – Pain associated with temporomandibular joint (TMJ)

Gender Eligibility: All

Minimum Age: 70 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • University of Wisconsin, Madison
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Neil Binkley, MD, Principal Investigator, Univ. of Wisconsin – Institute on Aging

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