Evaluation of Potential Vitamin D Effects on Muscle: a Pilot Study
Overview
People who do not have adequate amounts of vitamin D develop weakness of leg and arm muscles. This study will determine if vitamin D supplementation benefits muscle functions important for swallowing, bladder and bowel function.
Study Type
- Study Type: Interventional
- Study Design
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Primary Purpose: Treatment
- Masking: Double (Participant, Investigator)
- Study Primary Completion Date: May 2010
Interventions
- Other: Ergocalciferol (vitamin D2)
- 50,000 IU 3 times weekly for 4 weeks
Arms, Groups and Cohorts
- Placebo Comparator: 1
- oral placebo 3 times weekly
Clinical Trial Outcome Measures
Primary Measures
- change in lingual strength and perceived swallow function
- Time Frame: 4 weeks
Secondary Measures
- change in perceived bowel and bladder function
- Time Frame: 4 weeks
Participating in This Clinical Trial
Inclusion Criteria
- Patients who present for evaluation to the UW Geriatric clinic including Dr. Pryzbelski's subspecialty, or Osteoporosis clinics – Age 70 years or older – Cognitively intact, as determined by the attending physicians at above mentioned clinics Exclusion Criteria:
- History of, on ongoing, renal failure – History of liver failure – Known malabsorption – Known disorders of parathyroid function, hyper/hypocalcemia, or other abnormalities of calcium or phosphate metabolism – Known history of vitamin D intoxication or granulomatous disease – active seizure disorder – Pain associated with temporomandibular joint (TMJ)
Gender Eligibility: All
Minimum Age: 70 Years
Maximum Age: N/A
Are Healthy Volunteers Accepted: Accepts Healthy Volunteers
Investigator Details
- Lead Sponsor
- University of Wisconsin, Madison
- Provider of Information About this Clinical Study
- Sponsor
- Overall Official(s)
- Neil Binkley, MD, Principal Investigator, Univ. of Wisconsin – Institute on Aging
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