Effect of Conjugated Linoleic Acid on Body Fat in Overweight Children

Overview

The prevalence of overweight children has increased dramatically over the last decade, and many overweight children will remain overweight as adults. Conjugated linoleic acid (CLA), a naturally occurring dietary fatty acid, has shown promising results in reducing body fat among adults, and we propose to test the efficacy of CLA supplementation on body fat accretion in 6 to 10 year old children who are overweight or at risk of overweight.

Full Title of Study: “Effect of CLA Supplementation on Body Fat Accretion Among Children Who Are Overweight or at Risk of Overweight”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Treatment
    • Masking: Double (Participant, Investigator)
  • Study Primary Completion Date: June 2008

Interventions

  • Dietary Supplement: Conjugated linoleic acid
    • 3 grams per day of 80% CLA in safflower oil (2.4 grams active CLA isomers in triglyceride form)

Arms, Groups and Cohorts

  • Experimental: A
  • Placebo Comparator: B

Clinical Trial Outcome Measures

Primary Measures

  • body composition using DXA
    • Time Frame: 6 months

Secondary Measures

  • blood chemistry variables including fasting glucose and insulin, lipids, and liver enzymes
    • Time Frame: 6 months

Participating in This Clinical Trial

Inclusion Criteria

  • age 6 to 10 years – body mass index greater than 85th percentile – Tanner stage I Exclusion Criteria:

  • medical condition – dairy allergy

Gender Eligibility: All

Minimum Age: 6 Years

Maximum Age: 10 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • University of Wisconsin, Madison
  • Collaborator
    • Bunge Loders Croklaan
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Dale A Schoeller, PhD, Principal Investigator, University of Wisconsin, Madison

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