Metabolism of the Insecticide Permethrin

Overview

Military personnel are exposed to the insecticide permethrin when using the DOD Insect Repellent System. A urinary metabolite of permethrin that is in high abundance and is relatively stable may be an ideal biomarker of exposure to this pesticide. Monitoring such a biomarker can prevent over-exposure. The objectives are to identify the most abundant human urinary metabolite following dermal exposure; to utilize this information to develop rapid laboratory-based and field portable methods to monitor the degree of an individual's exposure to permethrin.

Full Title of Study: “CCRC:Identification and Development of Biological Markers of Human Exposure to the Insecticide Permethrin”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: N/A
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Basic Science
    • Masking: None (Open Label)

Detailed Description

Permethrin is applied to the forearm of the subject and remains for 8 hours. The exposed area is then washed with soap and water several times. 24 hour urine samples are collected at daily intervals for 192 hours. Blood and saliva samples are taken at pre-dose, 1, 3, 6, 9 12, 24, 48, 72, 96, 120, 144, 168 and 192 hours. Subjects must return to the clinic daily to drop off urine collections and have blood and saliva samples taken.

Interventions

  • Other: permethrin insecticide
    • 25 mg neat carbon-14 labelled permethrin applied dermally in isopropyl alcohol, once for 8 hours containing 1 microcurie of carbon-14

Clinical Trial Outcome Measures

Primary Measures

  • Concentration of individual metabolites in urine
    • Time Frame: 192 hours

Secondary Measures

  • total carbon-14 in serum
    • Time Frame: 192 hours
  • Total carbon-14 in saliva
    • Time Frame: 192 hours
  • Total carbon-14 in urine samples
    • Time Frame: 192 hours

Participating in This Clinical Trial

Inclusion Criteria

  • self-report healthy adult men and premenopausal women Exclusion Criteria:

  • unusual alcohol, drug, cigarette use for last 3 years – unusual exercise program for last 3 years – under the care of a physician for a disease – participated in any radioactive drug study – pregnant – lactating – people who rely more on their arm due to illness or injury – people with neurological or musculoskeletal diseases – use of permethrin in the last 6 months – people who apply pesticides as their primary occupation

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 50 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • University of California, Davis
  • Collaborator
    • U.S. Army Medical Research and Development Command
  • Provider of Information About this Clinical Study
    • Bruce D. Hammock, University of California
  • Overall Official(s)
    • Bruce D Hammock, PhD, Principal Investigator, University of California, Davis

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