Carbachols Headache-inducing Effect and Changes in Cerebral Blood Flow in Migraine Patients
Overview
The purpose of this study is to test if carbachol infusion induces headache in migraine subjects as well as intra- and extra-cerebral vasodilatation.
Full Title of Study: “Experimental Study That Investigates the Effect of an Acetylcholine Analogue in Terms of Headache and Changes in Intra- and Extra-cerebral Vessels During and After Infusion of Carbachol”
Study Type
- Study Type: Interventional
- Study Design
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Primary Purpose: Basic Science
- Masking: Double (Participant, Investigator)
- Study Primary Completion Date: October 2008
Detailed Description
To test if infusion of Carbachol induces headache in 12 migraine subjects as well as intra- and extra-cerebral vasodilatation in a double-blinded study
Interventions
- Drug: Carbachol
- 3 microgram per kg bodyweight infused intravenously
Arms, Groups and Cohorts
- Experimental: I
Clinical Trial Outcome Measures
Primary Measures
- Headache response after Carbachol infusion
- Time Frame: 1 day after infusion
Participating in This Clinical Trial
Inclusion Criteria
- Migraine without aura – Weight 50-100 kg Exclusion Criteria:
- Other significant diseases – Migraine 5 days prior to experiment
Gender Eligibility: All
Minimum Age: 18 Years
Maximum Age: 50 Years
Are Healthy Volunteers Accepted: No
Investigator Details
- Lead Sponsor
- Danish Headache Center
- Provider of Information About this Clinical Study
- Henrik Schytz/MD, Danish HC
- Overall Official(s)
- Henrik Schytz, MD, Principal Investigator, Danish Headache Center
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