Y402H Comlement Factor H Polymorphism and Age-Related Macular Degeneration in the Austrian Population
Overview
The aim of the study is to show a higher expression of the Y402H polymorphism in the complement factor H in patients with AMD compared to healthy individuals. Additionaly a correlation between a subsided infection with chlamydia and patients with AMD and a factor H polymorphism will be investigated. An interrelationship with the VEGF-plasma level shall give more hints into the pathomechanism of AMD.
Study Type
- Study Type: Interventional
- Study Design
- Allocation: N/A
- Intervention Model: Single Group Assignment
- Primary Purpose: Basic Science
- Masking: Single (Outcomes Assessor)
Interventions
- Procedure: drawing blood
Clinical Trial Outcome Measures
Primary Measures
- higher expression of the Y402H polymorphism in the complement factor H in patients with AMD compared to healthy individuals
Secondary Measures
- a correlation between a subsided infection with chlamydia and patients with AMD and a factor H polymorphism will be investigated. An interrelationship with the VEGF-plasma level shall give more hints into the pathomechanism of AMD
Participating in This Clinical Trial
Inclusion Criteria
- man and women over 18 years old – Filled out informed consentBereitschaft zur Teilnahme – Diagnosis of non-exudative/ exudative age related macular dgeneneration Exclusion Criteria:
- inherited retinal diseases – other aquired retinal/ macular – missing informed consent
Gender Eligibility: All
Minimum Age: 55 Years
Maximum Age: N/A
Are Healthy Volunteers Accepted: No
Investigator Details
- Lead Sponsor
- Rudolf Foundation Clinic
- Overall Official(s)
- Susanne Binder, M.D., Study Chair, Rudoulf Foundation Clinic
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