Y402H Comlement Factor H Polymorphism and Age-Related Macular Degeneration in the Austrian Population

Overview

The aim of the study is to show a higher expression of the Y402H polymorphism in the complement factor H in patients with AMD compared to healthy individuals. Additionaly a correlation between a subsided infection with chlamydia and patients with AMD and a factor H polymorphism will be investigated. An interrelationship with the VEGF-plasma level shall give more hints into the pathomechanism of AMD.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: N/A
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Basic Science
    • Masking: Single (Outcomes Assessor)

Interventions

  • Procedure: drawing blood

Clinical Trial Outcome Measures

Primary Measures

  • higher expression of the Y402H polymorphism in the complement factor H in patients with AMD compared to healthy individuals

Secondary Measures

  • a correlation between a subsided infection with chlamydia and patients with AMD and a factor H polymorphism will be investigated. An interrelationship with the VEGF-plasma level shall give more hints into the pathomechanism of AMD

Participating in This Clinical Trial

Inclusion Criteria

  • man and women over 18 years old – Filled out informed consentBereitschaft zur Teilnahme – Diagnosis of non-exudative/ exudative age related macular dgeneneration Exclusion Criteria:

  • inherited retinal diseases – other aquired retinal/ macular – missing informed consent

Gender Eligibility: All

Minimum Age: 55 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Rudolf Foundation Clinic
  • Overall Official(s)
    • Susanne Binder, M.D., Study Chair, Rudoulf Foundation Clinic

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