Organ Protection With Sevoflurane Postconditioning


Organ protection, volatile anesthetics, postconditioning, hepatic surgery

Full Title of Study: “Role of Volatile Anesthetics for Hepatic Protection in Ischemia-reperfusion: Postconditioning”

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Treatment
    • Masking: None (Open Label)
  • Study Primary Completion Date: August 2010

Detailed Description

This study aims at the evaluation of a potential attenuation of ischemic-reperfusion injury in the liver with sevoflurane postconditioning upon reperfusion.


  • Drug: Sevoflurane
    • 3.2 Vol % for postconditioning

Arms, Groups and Cohorts

  • Experimental: Sevoflurane
    • Sevoflurane for pharmacological postconditioning
  • Experimental: Propofol
    • Anesthesia maintenance with propofol instead of Sevoflurane postconditioning

Clinical Trial Outcome Measures

Primary Measures

  • Liver transaminase AST
    • Time Frame: Postoperative phase until discharge
    • Peak value

Secondary Measures

  • ALT peak value
    • Time Frame: Postoperative phase until discharge
  • Course of transaminases
    • Time Frame: From the day before surgery, to 6 hours after surgery, up to postoperative day 7
  • Postoperative complications
    • Time Frame: Postoperative phase until discharge
  • Length of hospital stay
    • Time Frame: Postoperative phase until discharge
  • Need for prolonged intensive care unit stay (>24 hours)
    • Time Frame: Postoperative phase until discharge

Participating in This Clinical Trial

Inclusion Criteria

  • older than 18 years
  • patients undergoing liver resection (benign or malignant tumors)

Exclusion Criteria

  • non-german speakers
  • laparoscopic liver resection
  • coagulopathy (platelets < 50'000/ml, Quick < 50%)
  • liver cirrhosis

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 90 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • University of Zurich
  • Provider of Information About this Clinical Study
    • BECK SCHIMMER Beatrice, Professor, University Hospital Zurich, Department of Anesthesiology
  • Overall Official(s)
    • 01 Studienregister MasterAdmins, Study Director, UniversitaetsSpital Zuerich

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