Effects of Acetazolamide and CO2 Inhalation on Exercise-induced Periodic Breathing in Heart Failure

Overview

To evaluate the effects of CO2 inhalation and acetazolamide treatment on exercise-induced periodic breathing in patients with chronic stable heart failure. Patients will be given CO2 (2%) during a constant workload exercise. Patients will be also evaluated by maximal cardiopulmonary exercise test without and with acetazolamide acute and chronic treatment.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: N/A
    • Intervention Model: Single Group Assignment
    • Masking: None (Open Label)
  • Study Primary Completion Date: July 2011

Interventions

  • Drug: acetazolamide
    • i.v. 500 mg of acetazolamide for the acute study and 500 mg of acetazolamide p.o. t.i.d. for two days

Arms, Groups and Cohorts

  • Experimental: Active Acetazolamide

Clinical Trial Outcome Measures

Primary Measures

  • Suppression of periodic breathing
    • Time Frame: two days

Secondary Measures

  • suppression of sleeping apnea
    • Time Frame: two days

Participating in This Clinical Trial

Inclusion Criteria

  • chronic heart failure in stable clinical condition – exercise-induced periodic breathing Exclusion Criteria:

  • comorbidities – NYHA class IV

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: 80 Years

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Centro Cardiologico Monzino
  • Provider of Information About this Clinical Study
    • Principal Investigator: Piergiuseppe Agostoni, MD PhD – Centro Cardiologico Monzino
  • Overall Official(s)
    • Piergiuseppe Agostoni, MD, PhD, Principal Investigator, Centro Cardiologico Monzino

References

Agostoni P, Bussotti M, Cattadori G, Margutti E, Contini M, Muratori M, Marenzi G, Fiorentini C. Gas diffusion and alveolar-capillary unit in chronic heart failure. Eur Heart J. 2006 Nov;27(21):2538-43. doi: 10.1093/eurheartj/ehl302. Epub 2006 Oct 6.

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