Effects of Acetazolamide and CO2 Inhalation on Exercise-induced Periodic Breathing in Heart Failure
Overview
To evaluate the effects of CO2 inhalation and acetazolamide treatment on exercise-induced periodic breathing in patients with chronic stable heart failure. Patients will be given CO2 (2%) during a constant workload exercise. Patients will be also evaluated by maximal cardiopulmonary exercise test without and with acetazolamide acute and chronic treatment.
Study Type
- Study Type: Interventional
- Study Design
- Allocation: N/A
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Study Primary Completion Date: July 2011
Interventions
- Drug: acetazolamide
- i.v. 500 mg of acetazolamide for the acute study and 500 mg of acetazolamide p.o. t.i.d. for two days
Arms, Groups and Cohorts
- Experimental: Active Acetazolamide
Clinical Trial Outcome Measures
Primary Measures
- Suppression of periodic breathing
- Time Frame: two days
Secondary Measures
- suppression of sleeping apnea
- Time Frame: two days
Participating in This Clinical Trial
Inclusion Criteria
- chronic heart failure in stable clinical condition – exercise-induced periodic breathing Exclusion Criteria:
- comorbidities – NYHA class IV
Gender Eligibility: All
Minimum Age: 18 Years
Maximum Age: 80 Years
Are Healthy Volunteers Accepted: No
Investigator Details
- Lead Sponsor
- Centro Cardiologico Monzino
- Provider of Information About this Clinical Study
- Principal Investigator: Piergiuseppe Agostoni, MD PhD – Centro Cardiologico Monzino
- Overall Official(s)
- Piergiuseppe Agostoni, MD, PhD, Principal Investigator, Centro Cardiologico Monzino
References
Agostoni P, Bussotti M, Cattadori G, Margutti E, Contini M, Muratori M, Marenzi G, Fiorentini C. Gas diffusion and alveolar-capillary unit in chronic heart failure. Eur Heart J. 2006 Nov;27(21):2538-43. doi: 10.1093/eurheartj/ehl302. Epub 2006 Oct 6.
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