Genomic Search for Childhood Obesity Genes-A Pilot Study

Overview

The purpose of this study is to screen a pediatric population (ages 2-8) for genes associated with childhood obesity.

Study Type

  • Study Type: Observational
  • Study Design
    • Time Perspective: Prospective
  • Study Primary Completion Date: June 2008

Detailed Description

The incidence of childhood obesity has been growing at an epidemic rate for the past several years, in part due to the lack of understanding of mechanisms at a molecular level. This study will screen a healthy general pediatric population age 2 to 8 for potential genes associated with childhood obesity using whole genomic gene arrays. Patients with BMI values equal to or greater than the 85th percentile will be compared to patients with a BMI below or equal to the 15th percentile. The INSIG2 gene will be specifically studied because of its identification in several populations of obese subjects. The differences in gene expression of the 2 groups will then be used to identify new genes for investigation in childhood obesity.

Interventions

  • Procedure: blood draws

Participating in This Clinical Trial

Inclusion Criteria

  • Ages 2-8, predominately Caucasian to minimize population stratification Exclusion Criteria:

  • Chronic diseases (diabetes, cancer, etc) and known syndromes

Gender Eligibility: All

Minimum Age: 2 Years

Maximum Age: 8 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • Children’s Mercy Hospital Kansas City
  • Provider of Information About this Clinical Study
    • Sponsor
  • Overall Official(s)
    • Merlin G Butler, M.D., Ph.D., Principal Investigator, Children’s Mercy Hospital Kansas City

Clinical trials entries are delivered from the US National Institutes of Health and are not reviewed separately by this site. Please see the identifier information above for retrieving further details from the government database.

At TrialBulletin.com, we keep tabs on over 200,000 clinical trials in the US and abroad, using medical data supplied directly by the US National Institutes of Health. Please see the About and Contact page for details.