Genomic Search for Childhood Obesity Genes-A Pilot Study
Overview
The purpose of this study is to screen a pediatric population (ages 2-8) for genes associated with childhood obesity.
Study Type
- Study Type: Observational
- Study Design
- Time Perspective: Prospective
- Study Primary Completion Date: June 2008
Detailed Description
The incidence of childhood obesity has been growing at an epidemic rate for the past several years, in part due to the lack of understanding of mechanisms at a molecular level. This study will screen a healthy general pediatric population age 2 to 8 for potential genes associated with childhood obesity using whole genomic gene arrays. Patients with BMI values equal to or greater than the 85th percentile will be compared to patients with a BMI below or equal to the 15th percentile. The INSIG2 gene will be specifically studied because of its identification in several populations of obese subjects. The differences in gene expression of the 2 groups will then be used to identify new genes for investigation in childhood obesity.
Interventions
- Procedure: blood draws
Participating in This Clinical Trial
Inclusion Criteria
- Ages 2-8, predominately Caucasian to minimize population stratification Exclusion Criteria:
- Chronic diseases (diabetes, cancer, etc) and known syndromes
Gender Eligibility: All
Minimum Age: 2 Years
Maximum Age: 8 Years
Are Healthy Volunteers Accepted: Accepts Healthy Volunteers
Investigator Details
- Lead Sponsor
- Children’s Mercy Hospital Kansas City
- Provider of Information About this Clinical Study
- Sponsor
- Overall Official(s)
- Merlin G Butler, M.D., Ph.D., Principal Investigator, Children’s Mercy Hospital Kansas City
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