The Impact of Resistance Exercise Training On Metabolic Dysregulation in Obese Children.


Impact of resistance training in prepubertal children with obesity focusing mostly in changes in body composition and markers of insulin resistance. Hypothesis is that this will show positive changes in this randomized controlled trial.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: Randomized
    • Intervention Model: Parallel Assignment
    • Primary Purpose: Prevention
    • Masking: None (Open Label)
  • Study Primary Completion Date: July 2008

Detailed Description

24 obese prepubertal obese children randomized to either resistance training program or usual care for 12 weeks. Baseline blood profiles and DEXA scans done before and after 12 weeks of training with the help of kinesiology graduates from Concordia University kinesiology department.


  • Behavioral: resistance training
    • 2 times a week resistance training

Arms, Groups and Cohorts

  • Experimental: RT
    • resistance training
  • No Intervention: Routine care
    • General counseling on increasing physical exercise

Clinical Trial Outcome Measures

Primary Measures

  • Changes in body composition as per DEXA scans
    • Time Frame: 12 weeks

Secondary Measures

  • Changes in insulin resistance as per HOMA score
    • Time Frame: 12 weeks

Participating in This Clinical Trial

Inclusion Criteria

  • Between 8-12y – Prepubertal – Not on medications with known impact on weight loss Exclusion Criteria:

  • Pubertal – Uncontrolled thyroid condition – Type 2 diabetes

Gender Eligibility: All

Minimum Age: 8 Years

Maximum Age: 12 Years

Are Healthy Volunteers Accepted: Accepts Healthy Volunteers

Investigator Details

  • Lead Sponsor
    • McGill University Health Centre/Research Institute of the McGill University Health Centre
  • Provider of Information About this Clinical Study
    • Laurent Legault,MD, MUHC
  • Overall Official(s)
    • Laurent Legault, MD, Principal Investigator, Montreal Children’s Hospital of the MUHC

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