Dandelion Juice in the Treatment of Dyshidrotic Hand Eczema

Overview

Dandelion juice has been used in herbal medicine for at least 1000 years. Vesicular hand eczema is a rare, but difficult to treat, type of hand eczema. One case report has shown that ingestion of dandelion juice could induce a beneficial effect on this type of eczema. The purpose of this study is to test whether this effect can be retrieved in other patients.

Study Type

  • Study Type: Interventional
  • Study Design
    • Allocation: N/A
    • Intervention Model: Single Group Assignment
    • Primary Purpose: Treatment
    • Masking: None (Open Label)
  • Study Primary Completion Date: December 2019

Detailed Description

Dandelion juice has been used in herbal medicine for at least 1000 years. One case report has shown a beneficial effect of this herbal remedy on dyshidrotic hand eczema, and the purpose of this pilot study is to test whether this effect can be retrieved in other patients. The patients are recruited from our out-patient clinic. Only patients with negative patch tests to Compositae are offered treatment with dandelion juice for 20-30 days.

Interventions

  • Drug: dandelion juice
    • 10 ml bid for 20-30 days

Arms, Groups and Cohorts

  • Other: 10 ml of dandelion juice twice daily

Clinical Trial Outcome Measures

Primary Measures

  • Improvement in dyshidrotic hand eczema in the study period assessed by HECSI score.
    • Time Frame: 3-4 weeks

Secondary Measures

  • Improvement in dyshidrotic eczema in the study period assessed by the patient (Visual Analog Scale).
    • Time Frame: 3-4 weeks

Participating in This Clinical Trial

Inclusion Criteria

  • Adult patients with dyshidrotic eczema for at least 1 year and negative patch test reactions to Compositae (tested within the last 3 years) and normal renal and hepatic blood tests. Exclusion Criteria:

  • Treatment with systemic steroids or other immunosuppressive/-modulating drugs, including UV therapy, within the last 3 months. – Pregnancy, lactation. – Compositae contact allergy. – Liver or gall bladder disease. – Abnormal renal or hepatic blood tests.

Gender Eligibility: All

Minimum Age: 18 Years

Maximum Age: N/A

Are Healthy Volunteers Accepted: No

Investigator Details

  • Lead Sponsor
    • Odense University Hospital
  • Provider of Information About this Clinical Study
    • Principal Investigator: Evy Paulsen, Consultant dermatologist, Ph.D. – Odense University Hospital
  • Overall Official(s)
    • Evy Paulsen, Dr., Principal Investigator, Department of Dermatology, Odense University Hospital, DK-5000 Odense C

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